mitotic phase - ANSWER mitosis - division of nucleus
cytokinesis - division of cytoplasm
prophase - ANSWER chromatin is further condensed to form chromosomes
spindle fibers begin to grow from 2 centrioles pushing them apart to a point where
they lie at opposite ends or poles of the cell
nuclear membrane disassembles
metaphase - ANSWER spindle fibers attach to the centromeres of the chromosomes
aligning them in the middle of the cell
anaphase - ANSWER centromeres that held the sister chromatids together separate
and sister chromatids are pulled by the spindle fibers toward the poles or ends of
the cell
each chromatid is a chromosome with its own centromere
cytokinesis begins
telophase - ANSWER new nuclear envelope forms around the chromosomes, a
nucleolus reforms within the nucleus
spindle fibers break up and disappear
chromosomes uncoil to form chromatin
cytokinesis continues
pathophysiology - ANSWER study of the disorder or breakdown of the human
body's function
pathogenesis - ANSWER development and evolution of a disease
affected by time, quantity, location, and morphologic changes
cell differentiation - ANSWER proliferated cells become different and specialized
begins after fertilization
, generalized to specific
atrophy - ANSWER decrease in cell size and number
hypertrophy - ANSWER increase in cell size
hyperplasia - ANSWER increase in the number of cells
metaplasia - ANSWER differentiated cell is replaced by another different type of
cell
dysplasia - ANSWER cells of different size, shape, and appearance
(DNA damage, lack of apoptosis, growth without growth factors)
cell injury - ANSWER most disease start with cell injury
can be reversible or irreversible
normal states, it is balanced with cell renewal
types: physical agents, radiation, chemical, biological, and nutritional imbalances
mechanism of injury: hypoxic injury - ANSWER ischemia, anoxia, necrosis
mechanism of injury: reperfusion injury - ANSWER replace the oxygen, free
radicals
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