Exam (elaborations)
ADVANCED PHARMACOLOGY- WEEK 4 EXAM WITH CORRECT ANSWERS
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ADVANCED PHARMACOLOGY- WEEK 4 EXAM WITH CORRECT ANSWERS
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ADVANCED PHARMACOLOGY-WEEK 4 EXAM WITH CORRECT
ANSWERS
Treatment for osteoarthritis - CORRECT ANSWERS-Traditional NSAIDs or
Second-Generation NSAID (Selective Cyclooxygenase-2 Inhibitor) Ex:
Celecoxib
What is the BLACK BOX WARNING for NSAIDs - CORRECT ANSWERS-may
increase the risk for myocardial infarction, stroke, and other thromboembolic
events
increase the risk for dangerous gastrointestinal adverse effects such as
bleeding, ulceration, and perforation.
Probenecid cautions that blood disorders (e.g., hemolytic anemia,
pancytopenia) may be attributable to glucose-6-phosphate dehydrogenase
(G6PD) deficiency, an inherited disorder. Patients at higher risk of this events
are? And what they should be screened for before receiving this drug? -
CORRECT ANSWERS-those of African or Mediterranean ancestry) should be
screened for G6PD deficiency before receiving the drug.
Probenecid should not be initiated at the beginning of an acute gout attack.
The drug may exacerbate acute episodes of gout; hence treatment should be
delayed until the acute attack has been controlled. Probenecid may induce
acute attacks of gout during the initial months of therapy after gout appears
to be controlled. If an attack occurs, What drugs can be added for relief. -
CORRECT ANSWERS-Colchicine or indomethacin
Adverse Reactions of Probenecid? - CORRECT ANSWERS-Probenecid is well
tolerated by most patients. Mild GI effects (nausea, vomiting, and anorexia)
occur occasionally. These can be reduced by taking the drug with food.
Probenecid can increase the risk for kidney damage, How can we educate
our patient to minimize this effect? - CORRECT ANSWERS-can be minimized
by alkalinizing the urine and consuming 2.5 to 3 L of fluid daily until a serum
uric acid level less than 6 mg/dL is achieved.
Drug interactions of Probenecid? - CORRECT ANSWERS-Aspirin and other
salicylates.
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