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Pharmacology Questions with correct Answers 100% and detailed solutions
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Pharmacology Questions with correct Answers 100% and detailed solutions
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Pharmacology Sample Items1. Ten months after starting procainamide therapy for cardiac arrhythmias, a 56-year-old man develops arthritis and other
symptoms consistent with drug-induced systemic lupus erythematosus. Results of a blood test are positive for antinuclear
antibodies. This finding is consistent with which of the following genetic polymorphisms in drug metabolism?
(A) Debrisoquine 4-hydroxylase deficiency
(B) Erythrocyte catechol-O-methyltransferase deficiency
(C) Glucose 6-phosphate dehydrogenase deficiency
(D) Phenytoin hydroxylase deficiency
(E) Slow acetylator phenotype
2. An 83-year-old man has a 2-month history of akinesia, rigidity, and tremor. He has been taking a drug for the past 7 years
to control severe behavioral and psychiatric symptoms associated with dementia, Alzheimer type. This adverse effect is
most likely mediated through which of the following?
(A) Anticholinergic effects
(B) Antidopaminergic effects
(C) Downregulation of γ-aminobutyric acid (GABA)
(D) Inhibition of norepinephrine reuptake
(E) Inhibition of serotonin reuptake
(F) Upregulation of GABA
3. A 23-year-old man with HIV infection has Pneumocystis jirovecii pneumonia. Therapy is started with trimethoprim-
sulfamethoxazole, and his pneumonia resolves. The pharmacotherapy was effective because of inhibition of which of the
following?
(A) Cell wall synthesis
(B) Dihydrofolate reductase
(C) Incorporation of p-aminobenzoic acid
(D) Incorporation of sterol into membranes
(E) Topoisomerase II
4. A 62-year-old man comes to the physician because of burning pain and tenderness of his right great toe 1 day after heavy
ethanol consumption. Physical examination shows erythema, swelling, warmth, and tenderness of the right great toe.
After a 2-week course of nonsteroidal anti-inflammatory drug treatment, his symptoms decrease in severity but do not
completely resolve. The serum concentration of which of the following is most likely increased in this patient?
(A) Calcium
(B) Carotene
(C) Creatinine
(D) Iron
(E) Orotic acid
(F) Phosphate
(G) Uric acid
5. A 62-year-old man is being treated with cisplatin for small cell carcinoma of the lungs. The efficacy of cisplatin depends
on interaction with which of the following?
(A) DNA
(B) DNA polymerase
(C) Growth factor receptors
(D) Reverse transcriptase
(E) Ribosomes
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, Pharmacology Sample Items
6. An 18-year-old woman comes to the physician because of nausea, vomiting, and abdominal pain 1 hour after ingesting
a glass of wine with dinner. Three days ago, she began antibiotic treatment for vaginitis after a wet mount preparation of
vaginal discharge showed a motile protozoan. This patient most likely has been taking which of the following drugs?
(A) Ceftriaxone
(B) Chloroquine
(C) Clindamycin
(D) Metronidazole
7. A 20-year-old woman comes to the emergency department after ingesting at least 30 tablets of an unknown drug. Initial
physical examination shows no abnormalities. Thirty-six hours later, serum AST activity is 1500 U/L, and serum ALT
activity is 2000 U/L. The drug this patient ingested is most likely which of the following?
(A) Acetaminophen
(B) Aspirin
(C) Chlorpheniramine
(D) Ibuprofen
(E) Prednisone
8. A 42-year-old woman who is a chemist is brought to the emergency department because of a 1-hour history of severe
abdominal cramps, nausea and vomiting, hypotension, bradycardia, sweating, and difficulty breathing due to
bronchospasm and congestion. Exposure to which of the following is most likely?
(A) Acrylamide
(B) Cyanogen bromide
(C) Isoflurophate (DFP)
(D) Phentolamine
(E) Propranolol
9. A 35-year-old woman is diagnosed with gastroesophageal reflux disease. Omeprazole is administered. Which of the
following is the most likely mechanism of action of this drug?
(A) Blockade of gastrin receptors
(B) Blockade of H1 receptors
(C) Blockade of M3 receptors
(D) Inhibition of H+–K+ ATPase activity
(E) Inhibition of synthesis of gastrin
10. In a 40-year-old man with hypertension, which of the following agents has the greatest potential to activate presynaptic
autoreceptors, inhibit norepinephrine release, and decrease sympathetic outflow?
(A) α1-Adrenergic agonist
(B) α2-Adrenergic agonist
(C) β1/β2-Adrenergic antagonist
(D) Angiotensin-converting enzyme inhibitor
(E) Calcium antagonist
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