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Exam (elaborations)

NR606 WEEK 4 QUESTIONS AND ANSWERS WITH SOLUTIONS 2024

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  • Course
  • NR 606
  • Institution
  • NR 606

NR606 WEEK 4 QUESTIONS AND ANSWERS WITH SOLUTIONS 2024

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  • August 4, 2024
  • 20
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • NR 606
  • NR 606
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NR606 WEEK 4 QUESTIONS AND
ANSWERS WITH SOLUTIONS 2024
develop schizophrenia - ANSWER -Many genes play a role

• as do epigenetic factors

• Heritability as high as 79%

-gene-environment interaction

-Environmental Triggers:

• Regular Cannabis Use

• Exposure to Early Life Trauma

➣Sexual Abuse

➣Emotional Abuse

➣Emotional Neglect

➣Bullying



schizophrenia Neuroanatomy - ANSWER -Mesocortical & ventromedial prefrontal cortex: negative and
affective symptoms



-Dorsolateral: cognitive symptoms



-Orbitofrontal & connections to the amygdala: aggressive, impulsive symptoms



Brain Circuits Affected in Schizophrenia: - ANSWER -Dopamine Pathways

• explain the (+) & (-) symptoms seen in schizophrenia & psychosis



Dopamine Role in Psychosis - ANSWER -leading hypothesis

• psychosis & schizophrenia associated with dysfunction of neurotransmitter dopamine (DA)

➣Traditionally surplus of dopamine

,Glutamate Role in Psychosis - ANSWER -primary excitatory neurotransmitter

-implicated in the overactivity of mesolimbic DA pathway in schizophrenia

-Glutamate hypoactivity may result in lost activation of the mesocortical dopamine pathway leading to
negative symptoms of schizophrenia



GABA is the primary _________ neurotransmitter - ANSWER inhibitory



Clinical domains of psychosis symptoms: Positive Symptoms - ANSWER -Hallucinations

-Delusions

-Thought disorder

-Hostility

-Excitability



Clinical domains of psychosis symptoms: Motor Symptoms - ANSWER -Motor delay

-Dyscoordination

-EPS, e.g.

• Parkinsonism

• Dyskinesia



Clinical domains of psychosis symptoms: Affective Symptoms - ANSWER -Depression

-Anxiety

-Suicidality



Clinical domains of psychosis symptoms: Cognition - ANSWER -Attention

-Working memory

-Verbal memory

-Visual memory

-Executive functioning

-Processing speed

, -Social conditioning



Clinical domains of psychosis symptoms: Negative Symptoms - ANSWER -Affective flattening

-Alogia

-Anhedonia

-Amotivation

-Asociality



Hallucinations: - ANSWER -perceptual experiences in the absence of external stimuli

• Auditory

• Visual

• Tactile (feeling)

• Olfactory

• Gustatory (tasting)



Delusions: - ANSWER -fixed false, irrational beliefs



• Persecution: delusions related to being threatened, victimized, or spied on



• Reference: delusions related to receiving personal messages from television (tv), radio, or actions of
others



• Somatic: delusions related to the body, including illness or the presence of foreign objects (e.g.
Sometimes people believe there are objects in their bodies; for example they might think they are
infested with insects.)



• Grandeur: delusions related to beliefs of special abilities or powers



• Control: delusions that actions and thoughts are controlled by others

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