*T or F:* IBS, a functional bowel disorder, is characterized by *abdominal pain/discomfort* and is
associated with *disturbed defecation*. - ✔✔True
*T or F:* IBS is a distinct disease rather than a common set of symptoms. - ✔✔False
*T or F:* The exact pathophysiology of IBS is known. - ✔✔False
*T or F:* IBS may result from an altered somatovisceral and motor dysfunction of the intestine as well as
visceral hypersensitivity. - ✔✔True
What are the factors contributing to visceral hypersensitivity in IBS? - ✔✔genetics, motility factors,
inflammation, colonic infections/bacterial overgrowth, mechanical irritation to local nerves,
stress/psychological factors
Which types of serotonin exist within the gut and are responsible for secretion, sensitization, and gastric
motility? - ✔✔HT3, HT4
In _____ pts, there's an increase in the postprandial levels of 5-HT when compared to healthy adults. -
✔✔IBS-D
*T or F:* IBS is not associated with excess mortality or long-term complications, but may cause changes
in sleep pattern, fatigue, anxiety, and stress. - ✔✔True
*T or F:* A major aspect of the diagnosis of IBS includes ruling out other diseases. - ✔✔True
What are some signs/symptoms found in other diseases, but not directly related to IBS? - ✔✔anemia;
rectal bleeding; weight loss; nocturnal sx; FH of colorectal cancer, inflammatory bowel disease, or celiac
sprue
, What diagnostic criteria can be used to aid in the workup of a patient suspected of having IBS? -
✔✔Rome criteria, Bristol stool subtype, Manning criteria (not used often in practice)
IBS is defined as? - ✔✔recurrent abdominal pain, on avg, at least 1 day per week in last 3 months (w/ sx
onset at least 6 months prior to diagnosis), associated w/ 2 or more of the following criteria:
- related to defecation
- associated w/ change in stool frequency
- associated w/ change in stool form
What are the 4 clinically distinct IBS subtypes? - ✔✔IBS with predominant constipation, IBS with
predominant diarrhea, IBS with mixed bowel habits, IBS unclassified
What is IBS with predominant constipation? - ✔✔patient reports that abnormal bowel movements are
usually constipation
What is IBS with predominant diarrhea? - ✔✔patient reports that abnormal bowel movements are
usually diarrhea
What is IBS with mixed bowel habits? - ✔✔patient reports that abnormal bowel movements are usually
both constipation and diarrhea
What is IBS unclassified? - ✔✔patients who meet diagnostic criteria for IBS but cannot be accurately
categorized into 1 of the other 3 subtypes
*(Bristol stool form scale)*
Which stool forms are considered constipation? - ✔✔Types 1 and 2
*(Bristol stool form scale)*
Which stool forms are considered diarrhea? - ✔✔Types 6 and 7
*T or F:* IBS clinically presents as:
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