epidemiology - ✔✔Affects twice as many women as men; Syndrome is neither life threatening nor
associated with development of GI diseases.
etiology - ✔✔Pain/discomfort from visceral hypersensitivity- Stool or gas in GI tract stimulates visceral
afferent fibers; Neurochemicals involved in bowel symptoms- Serotonin; Hormonal fluctuations-
symptoms worse with menstrual periods
patho - ✔✔Altered motility; Altered intestinal and colonic motility; Altered response to stress; Altered
responses to estrogen and testosterone
psychosocial factors - ✔✔Anxiety, Depression, Posttraumatic stress disorder, Stress can exacerbate
stress symptoms- May influence health care-seeking behavior
NOT with IBS - ✔✔Anemia, Fever, Persistent diarrhea, Rectal bleeding, Severe constipation, Weight loss
diagnostics - ✔✔No specific physical findings; Diagnosis made on the basis of symptoms and by
ruling out other conditions- Physical examination, Past health history, Psychosocial factors, Family
history, Drug/diet history, Painful menstrual periods
Rome III Criteria (diagnostics) - ✔✔At least 3 months, with onset at least 6 months previously of
recurrent abdominal pain or discomfort associated with two or more of the following: Pain relieved by
defecation, Onset of pain related to a change in stool
frequency, Onset of pain related to a change in stool appearance
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