ONS Chemotherapy Course
5-fluorouracil - correct answer-Antimetabolite
**leucovorin given concurrently
**take year round photosensitivity precautions
**cardiotoxicity
**Bolus can cause increased mucositis so have patient suck on ice chips for 10-15 min pre
and post. Can also cause hyperpigmentation at peripheral site
**Continuous can cause N/V/D and photosensitivity
adjuvant therapy - correct answer-used after the primary treatments have been completed to
decrease the chance that a cancer will recur
Agranulocytes - correct answer-T lymphocytes, B Lymphocytes, and Monocytes
Alkylating Agents - correct answer-synthetic chemicals containing alkyl groups that attack
DNA, causing strand breaks
Side Effects:
-secondary malignancies
-hypersensitivity reactions
-GI toxicities (N/V/D)
-highly emetogenic
-Renal Toxicity (need BUN and Creatinine prior)
Anthrayclines - correct answer-interfere with enzymes necessary for DNA to replicate
**work in all phases of the cell cycle
**Lifetime dose limits to prevent permanent cardiotoxicity and pulmonary fibrosis
Carboplatin (Paraplatin) - correct answer-alkylating agent-platinum based
**Hypersensitivity reaction
**harder for those >65
**harder on kidney function
**cause neurotoxicity
**Can cause hearing loss
**first 24 hours nausea
Cell Mediated Immunity - correct answer-Type of immunity produced by T cells that attack
infected or abnormal body cells.
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