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Prophecy Oncology test.
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Prophecy Oncology test.
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Prophecy Oncology testA 63-year-old man with a remote history of tobacco use presents with hematuria. He
undergoes a transurethral resection (TUR), which reveals T1 superficial bladder cancer.
- ANS-70%. TUR remains the surgical mainstay for the diagnosis and treatment of
stages Ta and T1 bladder cancer. After this procedure, the 10-year disease-specific
survival for Ta tumors is 85% and for T1 tumors it is 70%. The initial TUR provides
pathologic material to determine the histologic type, grade, and depth of invasion. The
findings help to direct additional therapy, dictate the follow-up schedule, and indicate
prognosis. In a literature review of more than 600 cases of T1 bladder tumors treated
only by TUR, 75% to 90% recurred by 5- and 10-year follow-up. A third of the cancers
progressed to muscle invasion within 5 years, 39% had progressed by 10 years, and
53% by 15 years.
A 68-year-old woman with a history of heavy tobacco use is found to have a solitary
lung nodule on chest computed tomography. Pathology from a recent bronchoscopy
reveals adenocarcinoma.What further staging work-up is necessary for this patient
before surgical resection? - ANS-Positron emission tomography (PET) scan.
Temozolomide (TMZ) - ANS-is an orally administered alkylating agent of the
imidazotetrazine class that is chemically related to dacarbazine. It is rapidly and
completely absorbed and passes through the blood-brain barrier, creating cerebrospinal
fluid concentrations that are 20% to 40% of plasma levels. The DNA repair protein
MGMT removes alkyl groups from the O6 position of guanine, a target of alkylating
agents, such as TMZ. In tumors, high expression of MGMT has been associated with
resistance to treatment with alkylating agents. Inactivation of the MGMT gene by
promoter methylation diminishes DNA repair activity and has been associated with long
What percentage of all breast cancer cases is related to genetic susceptibility? -
ANS-25%
Which of the following is NOT among the uses of PET imaging in the management of
cervical cancer? - ANS-Initial diagnosis
The use of functional imaging techniques, such as FDG-PET and PET-CT, to manage
patients with cervical cancer is constantly increasing. Current roles include pretreatment
staging and diagnosis of recurrent disease. Reports have also shown ability to predict
survival based on pre- and posttherapy scans. Cervical cancer spreads primarily
through direct extension, although lymphatic and hematogenous spread can result in
distant metastases. Traditionally, clinical examination and cross-projectional imaging
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