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Immunology Kuby Chapter 1 (1)
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Immunology Kuby Chapter 1 (1)
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Immunology Kuby Chapter 1Contrast selective and instructional theories of antibody specificity. - ANS-Cells have
side chain receptors (many different on cell)
Receptor specificity determined before exposure
Receptors interact with antigens - "lock and key"
Induces cell to produce and release more receptors
VS.
Antigen determine antibody specificity
Antibodies "fold" around antigen
Define antigen. - ANS-non-self or "rogue" self
Provokes immune response
Capable of reacting with products of immune response
Define attenuation and vaccine - ANS-weakened
Define cell-mediated and humoral immunity. - ANS-cell eating
serum (humerus) is an antitoxin
Define hypersensitivity, autoimmune, and immunodeficiency. - ANS-Hypersensitivity
Overzealous immune response to benign foreign antigens
Examples: allergies, asthma, anaphylaxis
Autoimmune disease
Targeting self-proteins or tissues
Immunodeficiency
Component of innate or adaptive immunity is absent or defective
Define immunity. - ANS-state of infection from infectious disease. "exempt"
Define immunology - ANS-study of the immune system
Has allowed for:
, Vaccine development (smallpox)
Transplantation
Pharmaceutical drug development (asthma)
Define PAMPs and PRRs. Which is associated with the pathogen? -
ANS-Pathogen-associated molecular patterns (PAMPs) -found on pathogens-
Common foreign structures that characterize whole groups of pathogens
Recognized by pattern-recognition receptors (PRRs) are found on white blood cells
(Toll-like receptors)
Define pathogens. - ANS-organisms that cause disease
Immunology and medical microbiology intertwined
Define phagocytes, serum, antitoxin, precipitin, agglutinin, immunoglobulins, antibodies,
passive immunity and active immunity - ANS-27:35s
Describe B cell receptors, antibodies and T cell receptors. - ANS-Membrane-bound
recognition molecules of B cells
Antibodies that are attached to the B cell
Secreted recognition molecules of B cells
Membrane-bound recognition molecules of T cells, allow T-cell and antigen to interact.
Once the antigen is bound the cell is activated
Describe phagocytosis. What cells are considered phagocytes? - ANS-monocyte,
neutrophil, macrophage, dendritic cells
PRRs are toll-like receptors
lysosome contain hydrolytic enzymes
Describe the 2 facets of the immune system, in your description include components of
the first, second, and third line of defense. - ANS-
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