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Kuby Immunology Chapter 11.
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Kuby Immunology Chapter 11.
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Kuby Immunology Chapter 11Activation-Induced Deaminase - ANS-Mediated somatic hypermutation. Produces
opportunity for mutation by altering deoxycytidine bases
B-cell memory function - ANS-provides a rapid/strong response to secondary infection
chemokine-directed B-cell migration - ANS-•B cells express CCR7 after Ag processing
•B cells move in the T-cell-rich zone until they encounter their counterpart Ag-specific T
cell
Class switch recombination - ANS-occurs within the GC after Ag contact.
Recombination occurs between donor and acceptor switch (S) regions
Clonal selection hypothesis - ANS-•Each B cell bears a single type of Ig receptor
•On stimulation, each cell will create a clone of cells bearing the same Ag receptor as
the original
Dark zone of germinal center - ANS-densely packed with proliferating B cells and SHM
Early experiments showed that animals had to receive what to produce antibody
responses against proteins? - ANS-bone marrow AND thymus grafts
exogenous pathway - ANS-BCR-mediated endocytosis: internalized Ag is processed.
Makes B-cells 10,000X more efficient at presentation
IgG-bearing memory cells - ANS-have undergone SHM producing higher-affinity
antibody
IgM-bearing memory B cells - ANS-•generated prior to somatic hypermutation
•Response to Ag inhibited by existing soluble Ab to Ag - low affinity BCR thus can't
compete
Light zone of germinal center - ANS-B cells interspersed with a network of FDCs
lipid rafts - ANS-lipids assembled in a defined patch in the cell membrane
Lyn - ANS-A tyrosine kinase important in lymphocyte signaling.
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