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Immunology Kuby - Exam 2
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Immunology Kuby - Exam 2
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Immunology Kuby - Exam 2All of the following are true regarding B cell development EXCEPT: - ANS-*B cells, like
T cells, are MHC class restricted*
At what stage of development does a B cell begin to display an IgM receptor? -
ANS-*Immature B cell*
At what stage of T cell development is pre-TCR expressed? - ANS-*DN*
At which stage during T cell development does cell commitment to the T cell lineage
occur? - ANS-*DN*
you gotta find out BOTH NEGATIVES before you COMMIT to Timothy
B cell development has a checkpoint to determine VhDJh rearrangement has produced
*a successful combination that can interact with a surrogate light chain*. At what point of
B cell development does this checkpoint occur? - ANS-*Between pro-B and pre-B*
Commitment of a CLP cell to the T cell lineage is dependent on expression of the
receptor for which ligand - ANS-*NOTCH*
bumping Timothy up a NOTCH by COMMITING to him
Deficiency in RAG-1 and/or RAG-2 can affect the proper development of which of the
following cell types, resulting in decreased numbers of circulating cells of those types? -
ANS-*Both A and B*
*Two of These*
Deletion of autoreactive B cells in bone marrow is called - ANS-*Central tolerance*
Expression of this transcription factor denotes passage into the pro-B stage, at which
point expression of non-B lineage markers is blocked - ANS-*PAX5* high 5 reject
How many different MHC classical class I proteins does each nucleated cell in a human
heterozygous at the MHC locus express? - ANS-*Six* Class 1 is 6, Class 2 is 12
If a B cell has a non-productive rearrangement at the *first K light chain allele*, what will
happen next? - ANS-Rearrangement will begin at the *second K light chain allele*
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