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Kuby Immunology Chapter 12.
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Kuby Immunology Chapter 12.
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Kuby Immunology Chapter 12_________ is responsible for both class switching and somatic hypermutation. -
ANS-AID, introduces point mutations within immunoglobulin
_________ possesses an ITIM that leads to the activation of a phosphatase which
regulates B cell response. - ANS-CD22
1. Describe the clonal selection hypothesis. (19) - ANS-one cell recognize a specific
antigen and it divides
10. Describe the experiment perform Miller, Mitchell and Mitchison. What was their end
conclusion? - ANS-
11. Where do antigens enter the lymph node? - ANS-subcapsular sinus
12. What prevents free diffusion of antigen throughout the lymph node? -
ANS-subcapsular sinus macrophages
13 min Bcells travel - ANS-enters paracortex, goes to cortex for follicular, paracortex,
back to cortex
13. Describe how small antigens are 'handled' in the lymph node. - ANS-enter the
follicular conduit
14. What is the function of subcapsular sinus macrophage? - ANS-Bind To the large
antigens
Presented by B cells
15. What is a reticular conduit? - ANS-Strands of collagen with cells woven inside to
form channels. They are semipermeable to APC
16. Describe how large antigens are 'handled' the in the lymph node. - ANS-Bind to
SSM then the antigen specific B cell
17. What is a SCS macrophage? - ANS-
, 18. What is an iccosome? Where are these structures found? What is the role of these
structures in B cell activation? (33min) - ANS-Complement receptors and Fc receptors
19. What happens after a B cell binds cell-associated with antigen? - ANS-
2. What is a t-dependent antigen? 21 min - ANS-Conentional response
leads to HEV
Determined importance of T cells in the production of antibodies
Mice were radiated not reconstituted with anything they werent able to make antibodies
Mice were radiated reconstituted with bone marrow cell alone they werent able to make
antibodies
20. What is upregulated after antigen binding in B cells? - ANS-MHC class II, CD80,
CD86 (1 to 2 hrs) you dont want it to go on too long because you dont want to have an
overproduction of tcells because chemokines can be produced and that is not good
21. When is a B cell 'ready' to present antigen to T cells? - ANS-
22. What type of T cell does a B cell present to? - ANS-
23. How and where does the B cell present antigen to the T cell? - ANS-36 min
24. What is the B cell response to IL-4? When is maximum IL-4 receptor expressed by
B cells? - ANS-Antigen exposed B cells up-regulate proliferative cytokine receptors for
IL-4 (released by T-cells)
Reaches maximum levels at 72 hours
25. Name the receptors expressed by an activated B cell. - ANS-
26. What is the function of CXCR5? What expresses the ligand to this receptor? - ANS-
27. What is the function of CCR7? What expresses the ligand to this receptor? -
ANS-Follow chemokines CCL19 and CCL21
28. How long does it usually take a B cell to find a 'matching' T cell? - ANS-
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