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Immunology Kuby Chapter 10 B-Cell Development
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Immunology Kuby Chapter 10 B-Cell Development
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Immunology Kuby Chapter 10 B-CellDevelopment
1. B lymphocytes are made in the:
A. blood stream.
B. bone marrow.
C. liver.
D. thymus.
E. totipotent cell. - ANS-Answer: B
Section: Introduction
Difficulty: 1
Hint: Location of B cell production from a HSC.
2. How long does B cell maturation from an HSC to a mature B cell take?
A. 1 to 2 hours
B. 1 to 2 days
C. 1 to 2 weeks
D. 1 to 2 months
E. 1 to 2 years - ANS-Answer: C
Section: Introduction
Difficulty: 1
Hint: B cell will begin to secrete antibodies within a few days of infection.
3. Which cell type is found in both B- and T-cell lineages?
A. Common lymphoid progenitors
B. Common pro-B-T cells
C. Immature B cell
D. Naïve lymphoid progenitor
E. Pro-B-T cell - ANS-Answer: A
Section: Introduction
Difficulty: 1
Hint: B cells belong to the lymphoid lineage.
4. This type of cell will leave the bone marrow and complete maturation in the spleen.
, A. Common lymphoid progenitor cell
B. hematopoietic stem cell
C. immature B cell
D. pro-B cell
E. pro-T cell - ANS-Answer: C
Section: Introduction
Difficulty: 1
Hint: B cells will see potential antigens in the germinal centers of secondary lymphoid
organs such as the spleen.
5. All of the following are true regarding B-cell development EXCEPT:
A. B cells complete maturation in the spleen.
B. B cells are mostly developed when they leave the bone marrow.
C. B cells, like T cells, are MHC class restricted.
D. Self-reactive B cells may be eliminated though apoptosis.
E. Self- reactive B cells may be rendered unreactive (anergic). - ANS-Answer: C
Section: Introduction
Difficulty: 2
Hint: B cells display IgD as their BCR.
6. Hematopoiesis produces:
A. B cells only.
B. Red blood cells only.
C. myeloid lineage cells only.
D. lymphoid and myeloid lineage cells.
E. erythorid, lymphoid, and myeloid lineage cells. - ANS-Answer: E
Section: The Site of Hematopoiesis
Difficulty: 2
Hint: Hematopoietic stem cells produce all blood cells.
7. Hematopoiesis begins at around day 7 after fertilization in mice. What is the site of
precursor cells at this stage of fetal development?
A. Bone marrow
B. Fetal liver
C. Placenta
D. Primitive organ
E. Yolk sac - ANS-Answer: E
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