Exam (elaborations)
Kuby Immunology Chapter 16 Tolerance, Autoimmunity, and Transplantation.
- Course
- Institution
Kuby Immunology Chapter 16 Tolerance, Autoimmunity, and Transplantation.
[Show more]
Seller
Follow
modockochieng06
Content preview
Kuby Immunology Chapter 16 Tolerance,Autoimmunity, and Transplantation
1. Central tolerance:
A. is the first step of tolerance mechanisms.
B. affects both T cells and B cells.
C. deletes cells that are autoreactive.
D. occurs in the bone marrow and thymus.
E. All of the above. - ANS-*All of the above*
2. Which of the following statements does NOT describe tolerogens accurately?
A. They can be the same molecules as immunogens.
B. They lead cells to become unresponsive.
C. They are part of peripheral tolerance.
D. They only affect B cells.
E. All of the above. - ANS-*They only affect B cells*
3. The tolerogenic response:
A. is not antigen specific.
B. leads to apoptosis but not anergy.
C. results in cells becoming non-responsive.
D. depends of the presentation context.
E. affects T cells only. - ANS-*results in cells becoming non-responsive*
4. Tolerance is promoted by all of the following circumstances EXCEPT:
A. high doses of antigen.
B. persistent antigen.
C. oral introduction of antigen.
D. presence of adjuvant.
E. low levels of costimulation. - ANS-**presence of adjuvant**
5. Tolerance is promoted by:
A. induction of anergy.
, B. induction of apoptosis.
C. regulation of activity of cells.
D. Both A and B.
E. All of the above. - ANS-**All of the above**
6. Apoptosis is:
A. similar to necrosis.
B. important in peripheral tolerance, but not central tolerance.
C. important in central tolerance, but not peripheral tolerance.
D. impaired in Fas-deficient systems.
E. None of the above. - ANS-**Impaired in Fas-deficient systems**
7. Maintaining immunologically protected sites, such as the eye:
A. allows sequestration of antigens.
B. reduces central tolerance.
C. can lead to autoreactivity secondary to injury.
D. can reduce background reactivity.
E. All of the above. - ANS-**All of the above**
8. Central tolerance employs all but which of the following mechanisms?
A. Apoptosis
B. Receptor editing
C. Positive selection
D. Negative selection
E. Clonal deletion - ANS-**Positive Selection**
9. Peripheral tolerance:
A. Is caused by costimulation without TcR-MHC+ peptide interaction.
B. is caused by TcR-MHC+ peptide interaction without costimulation.
C. Leads to anergy.
D. Both A and C.
E. Both B and C. - ANS-**Both B and C**
is caused by TcR-MHC+ peptide interaction without costimulation.
Leads to anergy.
10. Autoimmune diseases:
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller modockochieng06. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $7.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
80796 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now