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Summary Virology assignment and short notes
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- Institution
One document has short notes of the entire course, and the other contains an assignment given in class on the purification of viruses
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VIROLOGY=
:
→ Basis on which viruses are classified .
Order virales
-
corona ssRNA .
What is Ktv ? classificationon shape Viridae
→ →
Family
.
-
→ Terminal
Redundancy ? subfamily -
virinae
Viral needed ? Genus Virus
enzymes types why
→ -
, ,
"""" """" " " """ """""
→
"""
→ Icosahedral structure Pandorarims
lym
-
→
Enveloped viruses mimirirus
-0.74m
→
complex viruses Pandoravirus Salinas -2,5000 genes
material ?
How such less
genetic dulcis 4500genes
"
→ -
→ structure of rims ( components .
TMV → + VERNA -7 :
I group .
→ Virion , Virioid 1 subunit =) 3
proteins
definition Taka structural
Casper and Klug
→ virus
unit
of virus
.
→ Two
phases Triangulation .NO
→ viruses useful for ? all animal helical viruses are
?
→
Phage typing enveloped .
→ Functions of viral
proteins
? Hiv enveloped ,
helical -
→ difference b/w eukaryotes q prokaryotes ponvirws gemini .
, ,
complexions
Herpes simplex >
vaccines Cancer
treatment
those uniqueto Oculocutaneous albinism
enzymes catalyse
viral
'
:
[
viruses ↳ ° ↳ cured by gene
from RNA vector
mRNA
synthesis
.
DNAC viral) synthesis from
lack of melanin
RNA
vaccine virus ↳ HIV , retrovirus require reverse
transcriptase
↳ DNA dependent RNA
polymerase
HW
Endonuclease at
palindrome sequence .
Exonuclease at ends 32
page
, Viruses are classifiedon the basis of International committee of of viruses
ICTV taxonomy
→
diameter of virion RNA
polymerase acephagesretrovirus
-
of capsid
-
shape reverse
transcript ,
HIV
-
noofcapsomeres Baculorirus ,
myxoma pesticides .
-
no of
genes gene map
,
Herpes simplex virus vaccinations ,
Anti-cancer
material cured
type genetic
of OCA Oculouetanousalbanism bygenerator
-
/
Lysogenic lytogenic Acanthomoetapolyphagamimirines APMR
-
lipids proteins & Carbohydrates
enveloped not
,
-
or
>
envelope he " " '
immunological response symmetrical
-
capsid
-
-
icosahedral
> core
-
clinical features .
RNAIDNA of
-
location of DNA
replication ""
Protein
>
comprises
heoidity
variation
gggg.QR.p.gg
'
> controls
-
nature of host protein envelope germination
,
.
zFBf.EE?RNAandN
E-
protein intial cell membrane absorption .
Viral ←
→
Enzymes protein
enveloped helical vines
nucleic %gyg§→§ envelope
e.
Protein
↳ influenzae
necessary
for the
synthesis of
-
acid ICOSAHEDRAL STRICTURE :
Function of virus edges
protein ZOD 12 vertices 30
-
→
, ,
of
-
protection genetic material ↳
pentame.rs
i. 12 .
-
attachment to host >
equilateral triangles call same )
fusion with hosted/ membrane 3 axis of
symmetry 3 told fold Zfold
5
-
-
.
.
, , ,
theyre also usedas )
triangulation number number d- structural units (proteins
immune of host ↳ atleast 3in one subunit
enzymes
-
-
.
-
primers -
transcription factors structural units = 7×60
Viruses a re useful
for subunits in a
single face = total no of subunits
/ 20
HELICAL STRUCTURE
phage typing d- bacteria
:
-
=
of → Tobacco mosiac virus
source
.
enzymes
-
→ onemonomor surrounds DNA/ANA one side otitis heavier
pesticides generators
,
- _
i. ittormsa helix
aniti bacterial /cancer agents → Rabies
Influenzae .HN
, Herpes
.
.
EN ¥20s
-
:
☐
→ Howdorirushavesmall
genome
?
→
protein projects out spike protein orpeplomeres
host cell
use
proteins COMPLEX VIRUS :
-
/
core
membrane
-
code
efficiently overleapinggenes
-
Poxvinus brick
shape Nucleic
acid
multifunctionalproteins Outer
[ f- The DNA of
-
"
envelope
SHAPES OF VIRUS eucai.si#n-a-iSOMlVItUS ˢ%¥¥gens
anon
# \ µ lateral body
"
TAIL
spherical
PINS
filamentous ¥¥µ
# contains repeated sequences at its terminus
:: *
""
- ¥
-
spheroid
"
brick ↳ Terminal Redundancy
' '
- -
tadpole bullet
-
.
-
-
, V1
EPL/CATION :
ATTACHMENT
adheranceofvirus
→
particles to theplasma membrane
this isseeninthe attachment
very specific step
→ viruses are .
→
they bindtoaspecificreeeptorproteinonthecell surface
↳ these.pro/-einsarenotmadefo- attachment theyre present in ,
thecellandtherirusj.us/-aHachestoit .
→ cell
receptors or
receptors
co -
↳ so
they have
their own functions
E)
generalymadeupofglycoproteins ↳ chemokines →
receptor
↳ cell-cell contactand
rims select
receptors that are unique adhesion
→
aswell
and will affect
.
+ g those only cells .
receptor for rhinovirus KAMI
multiple receptors and be used
→ viruses
may
bind to ,
receptors can
by multiple
viruses .
→ virus first binds to receptor, ifitis.no/-suHicientitbindstoadiH-erentpotein ,
called
cosreceptor .
ENTRY INTO CELL Translocation Membrane Fusion .
Translocation →
only enveloped proteins
-
Membrane fusion host
home
fusion proteins to fuse with →
-
www.na.io →
receptor
Endocytosis cell
after receptors bind
-
.
virus translocated
;÷÷→÷÷¥→÷:É¥•
across membrane
Endocytosis
" "
"*
÷:&
.
-
Clathrin ② particle 's released
^
pH dependent
Cardin
into
€> cytoplasm
rhabdoirrus
→
influenzae
.
-
and
:*:& ,
.
Iatheincanolin independent →
pH independent herpesvirus.HN
-
.
¥É÷↳i;j;:É÷i÷:→ →
plant cells enters
throughout
material is released from the
Uncrating genetic before :
capsid .
attachment Guncoating simultaneously
- sometimes occurs even
entry eg
:
bacteriophage :
.
receptor triggers uncrating
others inside the cell PH
} triggers
-
presence of proteases
- .
-
at plasma membrane at nuclear membrane nuclear membrane
•
• with endosomes •
g)
I
=÷¥? ¥¥÷→☒→ /
±
I
→ ¥→ •
Eto ex
HERPES
:
SIMPLEX
?⃝
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