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PCN drug-drug interactions - ANS -aminoglycosides
-bacteriostatic antibiotics
-probenecid
Cephalosporin Generation 1 - ANS -cephalexin
-cephazolin
-cephadoxil
Cephalosporin and PCN - ANS Cross allergy w/PCN
Carbapenems - ANS not active against MRSA
Vancomycin treats - ANS gram positive
Vancomycin AE - ANS ototoxicity, nephrotoxicity, red man syndrome
Vancomycin main danger - ANS Hosp/vent. pneumonia in pt w/ Crcl less than 50 as it increases
mortality
Monobactams treats - ANS gram negative aerobic
Fosfomycin treats - ANS enterococcus and Ecoli
Aminoglycosides treat - ANS gram negative bacilli
Aminoglycosides adverse effects - ANS ototoxicity and nephrotoxicity
aminoglycosides peak and trough - ANS Peak: 30 min after IV or IM
Trough: divided- before next dose, daily-1 hr before next dose (value should be low: like zero)
Sulfonamides MOA - ANS inhibit folic acid synthesis
UTI drugs - ANS 1) TMP/SMZ and nitrofurantoin
2) levofloxacin & ciprofloxacin
UTI in pregnancy - ANS TMP/SMZ, Cipro, Levo, augmentin, cephalexin
recurrent UTI prophylaxis - ANS TMP
Recurrent UTI other tx - ANS SMZ 3 x week for 6 months; TMP or nitro at bedtime for 6 mos.
, Acute Bact Prostatitis Tx - ANS Floxacins
Tetracycline adverse effects - ANS -Yellow/brown discoloration of teeth
-hepatotoxicity
-photosensitivity
-GI
-suprainfection/superinfection
tetracycline absorption is impaired by - ANS -magnesium laxative
-antacids
-Calcium
-iron sup.
-milk
tetracycline treats - ANS -lyme dx
-anthrax
-helicobacter pylori
-mycoplasma
Linezolid treats - ANS VRE and MRSA
Telithromycin BBW - ANS muscle weakness w/myasthenia gravis
Dalfopristin/Quinupristin BBW - ANS reserve only for infection when not responding to vanco.
to delay resistance
Chloramphenicol BBW - ANS fatal aplastic anemia
Retapamulin and mupirocin tx - ANS topical treatment for impetigo
Mupirocin (topical) - ANS MRSA in nostrils
TB treatment - ANS RIPE (rifampin, isoniazid, pyrazinamide, ethambutol); rifapentine and
rifabutin
TB treatment is effective when - ANS no mycobacteria in sputum and no colonies present in
culture
TB second line injection drugs - ANS Amikacin & Capreomycin
MDR-TB - ANS resistant to isoniazid and rifampin
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