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ISBB HARR EXAM WITH QUESTIONS AND ANSWERS
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ISBB HARR EXAM WITH QUESTIONS ANDANSWERS
What type of serological testing does the blood bank technologist
perform when determining the blood group of a patient?
A. Genotyping
B. Phenotyping
C. Both genotyping and phenotyping
D. Polymerase chain reaction - ANSWER B Phenotyping, or the
physical expression of a genotype, is the type of testing routinely
performed in the blood bank. An individual, for example, may have
the AO genotype but phenotypes as group A.
If anti-K reacts 3+ with a donor cell with a genotype KK and 2+ with a
Kk cell, the antibody is demonstrating:
A. Dosage
B. Linkage disequilibrium
C. Homozygosity
D. Heterozygosity - ANSWER A Dosage is defined as an antibody
reacting stronger with homozygous cells (such as KK) than with
heterozygous cells (such as Kk). In addition to Kell, dosage effect is
seen commonly with antigens M, N, S, s, Fya, Fyb, Jka, Jkb, and the
antigens of the Rh system.
Carla expresses the blood group antigens Fya, Fyb, and Xga. James
shows expressions of none of these antigens. What factor(s) may
account for the absence of these antigens in James?
A. Gender
,B. Race
C. Gender and race
D. Medication - ANSWER C The frequency of Duffy antigens Fya and
Fyb varies with race. The Fy(a−b−) phenotype occurs in almost 70%
of African Americans and is very rare in whites. The Xga antigen is
X-linked and, therefore, expressed more frequently in women (who
may inherit the antigen from either parent) than in men.
Which of the following statements is true?
A. An individual with the BO genotype is homozygous for B antigen
B. An individual with the BB genotype is homozygous for B antigen
C. An individual with the OO genotype is heterozygous for O antigen
D. An individual with the AB phenotype is homozygous for A and B
antigens - ANSWER B An individual having the BB genotype has
inherited the B gene from both parents and, therefore, is
homozygous for B antigen.
Which genotype is heterozygous for C?
A. DCe\dce
B. DCE\DCE
C. Dce\dce
D. DCE\dCe - ANSWER A The genotype DCe\dce contains one C and
one c gene and is heterozygous for C and c antigens.
Which genotype(s) will give rise to the Bombay phenotype?
A. HH only
B. HH and Hh
C. Hh and hh
D. hh only - ANSWER D The Bombay phenotype will be expressed
,only when no H substance is present. The Oh type is expressed by
the genotype hh. Bombays produce naturally occurring anti-H, and
their serum agglutinates group O red cells in addition to red cells
from groups A, B, and AB persons.
Meiosis in cell division is limited to the ova and sperm producing four
gametes containing what complement of DNA?
A. 1N
B. 2N
C. 3N
D. 4N - ANSWER A Meiosis involves two nuclear divisions in
succession resulting in four gametocytes each containing half the
number of chromosomes found in somatic cells or 1N.
A cell that is not actively dividing is said to be in:
A. Interphase
B. Prophase
C. Anaphase
D. Telophase - ANSWER A Interphase is the stage in between cell
divisions. The cell is engaged in metabolic activity. Chromosomes
are not clearly discerned; however, nucleoli may be visible.
Which of the following describes the expression of most blood group
antigens?
A. Dominant
B. Recessive
C. Codominant
D. Corecessive - ANSWER C The inheritance of most blood group
genes is codominant, meaning that no gene or allele is dominant over
another. For example, a person who is group AB expresses both the
, A and B antigen on his or her red cells.
What blood type is not possible for an offspring of an AO and BO
mating?
A. AB
B. A or B
C. O
D. All are possible - ANSWER D A mating between AO and BO
persons can result in an offspring with a blood type of A, B, AB, or O.
The alleged father of a child in a disputed case of paternity is blood
group AB. The mother is group O and the child is group O. What type
of exclusion is this?
A. Direct\primary\first order
B. Probability
C. Random
D. Indirect\secondary\second order - ANSWER D An
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