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Summary Chemistry Temple Study Guides

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Here are some amazing summaries for more advanced biology courses at Temple. They definitely helped me succeed and get into medical school. Great outlines, mnemonics, detailed study guides.

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  • April 27, 2024
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Dr. Yesudas Review Session: Anti-Neoplastic Drugs  2 or 3 questions over slides 9 & 10, anthracyclines, non-anthracyclines o Know the rescue agents  Dexrazoxane for -rubicins  Mesna/2-Mercapto Ethane Sulphonate sodium for cyclophosphamide/ifosfamide  Leucovorin for methotrexate o Know irritants vs. vesicants  Irritants: damage occurring inside blood vessels (ex: cisplatin, bleomycin)  Vesicants: damage occurring outside blood vessels (ex: rubicins, nitrogen mustards) o Rubicins & nitrogen mustards are DNA-binding agents o Anthracyclines (-rubicins) MOA: intercalate b/w DNA bases  Rubicins cause irreversible cardiotoxicity & irreversible necrosis due to extravasation o Non-anthracyclines (bleomycin) MOA: fragmentation of DNA by targeting phosphodiester bonds  Bleomycin inhibits G2 phase  Major AEs of dermal toxicity & pulmonary toxicity due to low bleomycin hydrolase in those tissues  Camptothecins (-tecan): target Topoisomerase I o Know everything about Irinotecan b/c will have 1 exam question & 1 final question  Prodrug that is converted to SN-38  diarrhea major AE  Screen for UGT1A1 fxn before administration  Podophyllotoxins (-side): target Topoisomerase II  Vinca alkaloids (vincristine/vinblastine) MOA: inhibit microtubule formation  Taxanes (-taxel) MOA: inhibit microtubule disassociation  Anti-cancer antibodies: o Trastuzumab: HER2+ cancers, causes reversible cardiac toxicity o T-DM1: linked to cytotoxic emtansine for those who fail trastuzumab o Pertuzumab: binds & inhibits HER2 o Pembrolizumab: PD1 receptor inhibitor o Bevacizumab: VEGF inhibitor, inhibits angiogenesis in tumors, major AE: wound healing complications o Imatinib: tyrosine kinase inhibitor o Bortezomib: proteasome inhibitor o Palbociclib: cdk 4/6 inhibitor  All alkylating agents have same MOA: covalently cross-linking DNA  breaks DNA o Nitrogen mustards  Mechlorethamine: causes vesicant extravasation  Cyclophosphamide: not a vesicant because is a prodrug; causes hemorrhagic cystitis due to acrolein (mesna rescue agent)  Ifosfamide: more severe hemorrhagic cystitis because longer half-life o Busulfan: causes pulmonary fibrosis, 100% myelosuppression so used for transplant prophylaxis o ThioTEPA: activated in low pH o Nitrosureas (carmustine, lomustine) are used for brain tumors because they can pass BBB o Cisplatin: know everything about this drug!!  Platinum analog, highly emetogenic, marrow-saving drug  Causes irreversible oto & nephrotoxicity  Avoid amphotericin B coadministration  Rescue agent: amifostine o Oxaliplatin: cold sensitivity AE o Procarbazine: disulfiram-like rxn  No questions after slide 77 for Monday’s exam  Do not need to know drugs that are not starred on drug list  For the final: make sure to know slide 91, especially difference between tamoxifen, anastrozole, fulvestrant o Fulvestrant is for recurring breast cancer, degrades estrogen receptors

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