ASCP MLS (Anemia ) EXAM QUESTIONS WITH ACCUR ATE SOLUTIONS The morphological classification of anemias is based on a. reticulocyte count b. etiology of the disease c. RBC indices d. Clinical signs and symptoms Verified Answer -c. RBC indices Reticulocytosis usually indicates a. accelerated erythropoiesis b. neoplastic process c. aplastic anemia d. response to inflammation Verified Answer -a. accelerated erythropoiesis RBC morphology in sickle cell trait is typically a. normocytic, normochromic b. normocytic, hypochromic c. microcytic, normochromic d. microcytic, hypochromic Verified Answer -a. normocytic, normochromic Which of the following will NOT be found on the hemoglobin electrophoretic pattern of a patient with sickle cell disease? a. 20% - 40% Hemoglobin A b. 5% - 20% Hemoglobin F c. 2% - 4% Hemoglibin A1 d. 80% - 95% Hemoglobin S Verified Answer -A. 20% - 40% Hemoglobin A Methemoglobinemia is characterized by all of the following EXCEPT: a. can be caused by deficiency of methemoglobin b. Oxidation of the heme iron to the ferric form c. May result in Hemoglobin M disease d. Shifts hemoglobin dissociation curve to right Verified Answer -d. shifts hemoglobin dissociation curve to right A cellulose acetate electrophoresis revealed a large band of hemoglobin in the hemoglobin S position. This band was quantified as 95%. The peripheral smears revealed 70% target cells. The Dithionite solubility test was negative. Based on this information, the hemoglobin is MOST LIKELY a. Hemoglobin Bart's b. Hemoglobin C c. Hemoglobin E d. Hemoglobin S e. Hemoglobin D Verified Answer -e. Hemoglobin D Cellulose acetate is performed on a patient with known homozygous hemoglobin S who received red blood cell transfusions two days ago. What hemoglobins would be expected to be found? a. S and F b. A and F c. S, A, and F d. S, A, F, and A2 Verified Answer -D. S, A, F, and A2 All of the following are usually found in Hemoglobin C disease EXCEPT: a. Lysine substituted for glutamic acid at the sixth position of the Beta chain b. Hemoglobin C crystals c. Fast motility toward the anode on cellulose agar at pH 8.6 d. codocytes Verified Answer -c. Fast motility toward the anode on cellulose agar at pH 8.6 Which one of the following is generally TRUE in Hereditary Persistence of Fetal Hemoglobin (HPFH) a. The major hemoglobin consists of four gamma chains b. Beta and delta chain synthesis is decreased c. The defect is a deletion of two alpha chains d. Elution performed in the KB test will show only "ghost" cells Verified Answer -b. beta and delta chain synthesis is decreased Which one is NOT a characteristic of hemoglobin H? a. shifts the hemoglobin dissociation curve to the left b. precipitates out and takes on a "golf ball" appearance in supravital stain c. causes a macrocytic, normochromic anemia
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