CHM 435 Exam 2
Lead Compound - Answer-A lead compound is a compound that acts as the starting point for drug design and development. It may have disadvantages such as low activity or the presence of side effects, but it acts as a starting point for the development of a better agent.
Which of ...
which of the following needs to be established bef
what is the term used for the automated in vitro t
there are several sources and methods of discoveri
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CHM 435 Exam 2
CHM 435 Exam 2
CHM 435 Exam 2
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CHM 435 Exam 2
Lead Compound - Answer-A lead compound is a compound that acts as the starting point for
drug design and development. It may have disadvantages such as low activity or the presence
of side effects, but it acts as a starting point for the development of a better agent.
Which of the following needs to be established before the search for a lead compound takes
place?
A) the Pharmacophore
B) Structure-Activity relationships
C) a Bioassay
D) Patents - Answer-C
The lead compound has to have some sort of desirable biological activity, and so a bioassay to
detect that activity is required. Structure-activity relationships and the identification of a
pharmacophore are stages in the drug design process that come after the discovery of the lead
compound. Patents are taken out at a later stage once potentially useful compounds have been
designed and developed.
What is the term used for the automated in vitro testing of large numbers of compounds using
genetically modified cells?
A) Robotic Testing
B) High throughput screening
C) multiscreening
D) nanotechnology - Answer-B
As well as being automated and capable of handling large numbers of compounds, high
throughput screening (HTS) can be carried out on small scale, allowing results to be obtained
quickly and efficiently.
There are several sources and methods of discovering new compounds. Which of the following
is most likely to lead to the discovery of a complex structure quite unlike any other previously
discovered?
A) combinatorial chemistry
B) database mining
C) screening plant extracts
D) me too drugs - Answer-C
There are no preconceived ideas when screening plant extracts for active lead compounds.
Some natural products are quite bizarre in structure!
Combinatorial Chemistry - Answer-Combinatorial chemistry involves the synthesis of a large
number of compounds
using a standard synthetic route, and so the types of structures that will be
synthesised are predictable and belong to a similar family of compounds.
Database Mining - Answer-Database mining involves the computerised search of known
compounds for
particular pharmacophores.
Me-too drugs - Answer-Me-too drugs are analogues of an established drug
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