Clinical Chem Test Bank (Final Exam)
1. In which of the following disorders would the maternal serum level of 1-fetoprotein be elevated?
A. Neural tube defect.
B. Cardiac ischemia.
C. Down syndrome.
D. Small cell lung carcinoma
2. Which of the following is FALSE about PSA?
A. It is a single-...
1). 1. in which of the following disorders would the maternal serum level of 1-fetoprotein be
elevated?
a. neural tube defect.
b. cardiac ischemia.
c. down syndrome.
d. small cell lung carcinoma
Ans: A. Neural tube defect
2). 2. which of the following is false about psa?
a. it is a single-chain glycoprotein
b. it is used as a tumor marker
c. it is not elevated in benign prostatic hyperplasia
d. it is quantified in serum by immunoassays
Ans: C. It is not elevated in benign prostatic hyperplasia.
3). 3. which of the following biomarkers is elevated in nonmucinous epithelial ovarian cancer?
a. ca 15-3
b. ca 19-9
c. ca 125
d. cea
Ans: C. CA 125
4). 4. which of the following is a sialylated lewis blood group antigen associated with
colorectal cancer?
a. ca 125
b. ca 15-3
c. psa
d. ca 19-9
Ans: D. CA 19-9
5). 5. which of the following biomarkers are elevated in advanced stages of breast cancer?
a. total and free psa
b. cea and alpha-fetoprotein
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, c. ca 15-3 and ca 549
d. dupan-2 and gastrin
Ans: C. CA 15-3 and CA 549
6). 6. which tumor marker is associated with cancer of the urinary bladder?
a. ca 125
b. ca19-9
c. ca 50
d. nuclear matrix protein
Ans: D. Nuclear matrix protein
7). 7. what is the primary clinical usefulness of measuring carcinoembryonic antigen?
a. diagnosis of lung cancer
b. diagnosis of colorectal cancer
c. screening for breast cancer
d. monitoring for recurrence of colon cancer
Ans: D. Monitoring for recurrence of colon cancer
8). 8. which of the following is used to assess the usefulness of trastuzumab (herceptin®)
therapy for breast cancer?
a. ca 15-3
b. her-2/neu
c. ca 125
d. prolactin
Ans: B. HER-2/neu
9). 9. which type of hcg test would be most useful to assess a person suspected of having
testicular cancer?
a. plasma immunoassay for intact hcg and the β-hcg subunits
b. plasma immunoassay fro the free alpha and β-hcg subunits
c. urine assay for hcg-β core
d. plasma immunoassay for intact hcg only
Ans: A. Plasma immunoassay for intact hCG and the β-hCG subunits
10). 10. a markedly elevated serum afp is associated with which of the following?
a. ovarian cancer
b. lung cancer
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, c. hepatoma
d. breast cancer
Ans: C. Hepatoma
11). 11. which of the following assays is recommended as a screening test for colorectal
cancer in persons over 50 years of age?
a. fecal typsin
b. afp
c. bta
d. occult blood t test
Ans: D. Occult blood test
12). 12. which of the following must be determined to calculate diagnostic specificity?
a. true-negatives and false-positives
b. true-positives and false-positives
c. true-positives and false-negatives
d. true-negatives and false-negatives
Ans: A. True-negatives and false-positives
13). 13. a new tumor marker assay for prostate specific antigen (psa) is evaluated for
sensitivity by testing serum samples from patients who have been diagnosed as having
prostate cancer. the following results were obtained:
number of prostate cancer patients who tested positive by the new assay = 42 out 46
number of patients who did not have cancer and tested negative by the new assay = 31
out of 32
what is the sensitivity of the new assay for psa?
a. 98.0%
b. 95.0%
c. 91.3%
d. 88.5%
Ans: C. 91.3%
14). 14. which statement below best describes the molecular difference between free psa
(fpsa) and complex psa (cpsa)?
a. free psa is bound by compounds such as act, pci, api, or amg
b. free psa is an active form that can complex with protease inhibitors
c. free psa is not bound by compounds such as act, pci, api, or amg
d. free psa cannot be detected in serum, whereas complex psa can
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, Ans: C. Free PSA is not bound by compounds such as ACT, PCI, API, or AMG
15). 15. the production of alpha fetal protein (afp) in a healthy individual is best reflected by
which of the following statements?
a. the production of afp remains the same through life
b. the production of afp declines rapidly at birth and healthy adults and children have
negligible or undetectable levels in serum
c. the production of afp declines rapidly at birth and healthy adults and children have
higher than normal levels in serum
d. the production of afp declines rapidly at birth and healthy adults and children have
negligible or undetectable levels in serum
Ans: D. The production of AFP declines rapidly at birth and healthy adults and children
have negligible or undetectable levels in serum
16). 16. the combination of squamous cell carcinoma antigen (scca) and cyfra 21-1 test results
can be used to provide reliable laboratory data for the differential diagnosis of which
disease?
a. nonsquamous cell lung carcinoma
b. pancreatic cancer
c. liver cancer
d. pulmonary embolism
Ans: A. Nonsquamous cell lung carcinoma
17). 17. a new test for breast cancer is found to have a sensitivity of 85.0% and a specificity of
90.0%. if the prevalence of breast cancer is 3.5% in women over 45 years old, what is the
predictive value of a positive test result (pv+) in this group?
a. 60.0
b. 50.5
c. 30.0
d. 23.6
Ans: D. 23.6
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