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Pcol questions with correct answers

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  • PCOL
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  • PCOL

Pcol questions with correct answers

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  • March 19, 2024
  • 6
  • 2023/2024
  • Exam (elaborations)
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  • PCOL
  • PCOL
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Pcol questions with correct answers
are produced by altering the normal functions of cells and tissues in the body via one of four general mechanisms Correct Answer-Drug effects
Four general mechanisms Correct Answer-Interaction with receptors
Alteration of the activity of enzymes
Antimetabolite action
Nonspecific chemical or physical interactions
naturally occurring target macromolecules that mediate the effects of endogenous physiologic substances such as neurotransmitters and hormones Correct Answer-
Interaction with receptors
Four major classes of drug-receptor interactions Correct Answer-Ligand-activated ion channels
G-protein-coupled receptors
Receptor-activated tyrosine kinases
Intracellular nuclear receptors
-acetylcholine interacting with anicotinic receptor that is a nonspecific Na+ /K+ -specific acting in nicotinic receptor
-fed na receptor channels Correct Answer-Ligand-activated ion channels
G-protein-coupled receptors compose the largest class of receptors
-most abundant receptor Correct Answer-G-protein-coupled receptors Many growth-related signals (e.g.,insu-lin) are mediated via membrane receptors that possess intrinsic tyrosine kinase activity for the insulin receptor
activate by tyrosine kinase Correct Answer-Receptor-activated tyrosine kinases
-receptor inside the cell cause mostly found in cell membrane(nucleus)
-steroid or cortisol drugs
Ligands(e.g., cortisol) for nuclear receptors are lipophilic and can diffuse rapidly through the plasma membrane Correct Answer-Intracellular nuclear receptors
by activation or inhibition of the enzyme's
catalytic activity Correct Answer-Alteration of the activity of enzymes
in which the drug, acting as a nonfunctional analogue of a naturally occurring metabolite, interferes with normal metabolism Correct Answer-Antimetabolite action
such as those caused by antacids, osmotic agents, and chelators Correct Answer-
Nonspecific chemical or physical interactions
expresses an individual's response to increasing doses of a given drug. The magnitude of a pharmacologic response is proportional to the number of receptors with which a drug effectively interacts
more receptors that you have activated more effects to happen Correct Answer-The
graded dose-response curve
effect will be stagnant even dose increases
slowing down till reacg emax Correct Answer-Emax

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