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Rush NSG 531 Advanced Pharmacology Exam 2 questions answers 2024 A GRADED 100 VERIFIED $12.49   Add to cart

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Rush NSG 531 Advanced Pharmacology Exam 2 questions answers 2024 A GRADED 100 VERIFIED

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Rush NSG 531: Advanced Pharmacology Exam 2 questions & answers 2024 ( A+ GRADED 100% VERIFIED) Potency Efficiacy Non-competitive (irreversible) antagonist LDR curve Competitive (reversible) antagonist LDR curve Synthesis of NE Bethanechol Pilocarpine Atropine Epinephrine binding affinity ...

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  • March 15, 2024
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Rush NSG 531: Advanced Pharmacology Exam 2
questions & answers 2024 ( A+ GRADED 100%
VERIFIED)

1). Potency

 Ans: Dose of drug required to produce given effect; 50% of maximal response the drug
is capable of producing


2). Efficiacy

 Ans: Maximal response a drug is capable of producing


3). Ka

 Ans: Volume needed to get one mole of an unbound drug when 50% of target receptors
are occupied. L/mole


4). Kd

 Ans: Concentration of drug in the plasma when 50% of the target receptors are
occupied. Mole/L


5). Non-competitive (irreversible) antagonist ldr curve

 Ans: Moves to the right and down


6). Competitive (reversible) antagonist ldr curve

 Ans: Moves to the right and parallel


7). Synthesis of ne

 Ans: Occurs at adrenergic neuron; Tyrosine to DOPA to dopamine to NE. Binds to alpha
and beta receptors. Degraded by COMT and MAO.



Bethanechol


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, 8).
 Ans: Muscarinic agonist prototype. Selective, binds to M3 receptors in the bladder and
causes bladder muscle contraction and sphincter relaxation.
Indicated for urinary retention in postop or pp pts.
AEs: salivation, lacrimation, bronchospasm, diarrhea, and bradycardia


9). Pilocarpine

 Ans: Muscarinic agonist for glaucoma. Causes ciliary muscle contraction.


10). Atropine

 Ans: Muscarinic antagonist prototype. Nonselective competitive muscarinic
antagonist.
Indicated for: bradycardia, pupil dilation (mydriasis) for eye exams, GI hypermotility
Contraindications: Glaucoma, urinary retention, tachycardia
AEs: Dry mouth, blurred vision, urinary retention, constipation, anhidrosis


11). Epinephrine binding affinity

 Ans: Binds to all four adrenoreceptors but has a greater affinity for beta


12). Ne binding affinity

 Ans: Binds to alpha 1, alpha 2, and beta 1 but has greater affinity for alpha


13). Alpha 1 receptors

 Ans: Eyes: produce mydriasis
Blood vessels in skin, viscera, gut, kidney, brain: vasocontriction
GU: prostate contraction and ejaculation, smooth muscle contraction of internal urethral
sphincter


14). Phenylephrine

 Ans: Alpha 1 receptor, prototypic agonist; used to induce mydriasis


15). Pseudoephedrine

 Ans: Alpha 1 receptor, prototypic agonist; nasal decongestant




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