Drug phases: absorption ---> distribution ---> metabolism---> excretion
- When taking an oral drug as a solid form it first needs to disintegrate and then dissolution
- Liver is responsible for MOST metabolismmv
- Some drugs move freely, others need a protein or enzyme to travel
- First pass effect: when passed through the liver and it makes it bioavailable and makes
some part of it inactive(this is why we sometimes give a higher PO dose due to the3 first
pass effect)
- Bioavailability: what percentage of administered drug available for activity after the first
pass (much higher with IV drugs bc it doesn't have a first pass effect)
Half Life: the time it takes for the drug concentration to go down to 50% - after 1 half life, the
concentration in the body will be half of the starting dose.
Loading Dose: an initial higher dose to help reach a therapeutic level
Pharmacodynamics: study of way drugs affect body
- Primary effect: desirable response
- Secondary effect: desirable or undesirable
- Therapeutic index: good response without too many side
, effects Therapeutic drug monitoring
- Peak drug level 30min-60min after IV admin or hours after oral admin
- Trough drug level drawn right before the next dose
- If peak is too high then lower dose, if peak is too low then increase
- If trough is too high then space out the doses longer , if too low then increase frequency
of drug
Additive: sum of effects of 2 drugs
Synergistic: effect is much greater than effects of either drug alone
Antagonistic: 1 drug reduces or blocks the effect of other drug
Exam #1
Study Guide
Test may include information from:
· McCuistion Text
o CH 1-5
o CH- 9
o CH 12, 13, 14
o CH 35, 36
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Millenialnurse. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $23.99. You're not tied to anything after your purchase.
