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PC707 Module 1 Questions And Answers
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PC707 Module 1 Questions And Answers
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PC707 Module 1 Questions And AnswersWhat is prescriptive authority?
Legal right to prescribe drugs
Is the Physicians Desk Reference a reliable source to use when prescribing drugs?
No--it is not evidence-based and it is not updated
What is the sunshine act?
-part of the affordable care act
-limits providers on accepting gifts from pharmaceutical companies
-reduces bias
What is pharmacology?
-study of the drugs and their actions and effects on living things
-legal drugs, illegal drugs, prescription drugs, OTC drugs
How does the FDA define drugs that they approve?
-chemicals that have been proved for safety and efficacy
What must providers consider when prescribing?
-the dose
-the route of administration
-indications -side effects of consequence
-adverse effects
-contraindications
-significant drug-drug interactions
-appropriate monitoring
-treatment of side effects if necessary
What is pharmacokinetics?
-how drugs move in the body and what the body does with it
How does pharmacokinetics influence prescribing?
-the route
-the dosage needed
-dosing intervals
What are the 4 aspects of pharmacokinetics?
-absorption
-distribution
-metabolism
-excretion
What affects bioavailability the most?
PO administration
What is a pro-drug?
-a drug that needs to be metabolized to become "activated"
What is the major organ of metabolism? -Liver
-Uses enzymes called "CYPs"
-these enzymes can induce or inhibit metabolism
What is protein-binding?
-drugs that have a high affinity for proteins will bind with them and therefore become unable to bind to receptor sites
-in order to activate receptors they must be free circulating molecules
What is the half-life of a drug?
-how long it takes for a drug at its original amount to be reduced
by 50%
Why is it important to know the half-life of a drug?
-to help determine dosing intervals to maintain therapeutic levels
What is the first-pass effect?
-alteration of the drug dose by metabolism before it reaches systemic circulation
-only happens with PO medications
What are the genetic variances of metabolism?
-poor metabolizers (certain enzymes are little to none)
-intermediate metabolizers
-extensive metabolizers (NORMAL)
-ultra-rapid metabolizers (duplicate genes to make extra enzymes)
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