GMS 6552 Exam 1 Questions and
Answers 100% Accurate
Molecular Drug Targets - ANSWER-Receptors-45%
Enzymes-28%
Hormones-11%
Unknown-7%
Ion Channels-5%
DNA-4%
Channel-Linked (Ionotropic) Receptors - ANSWER-Produce cellular effects in
milliseconds
Nicotinic ACh receptor
GPCRs - ANSWER-Effects happen in seconds
Muscarinic ACh receptor
Kinase-linked receptors - ANSWER-Effects happen in minutes
Insulin receptor
Receptors linked to gene transcription - ANSWER-Effects happen in hours
Estrogen receptor
Heterotrimeric G proteins - ANSWER-alpha, beta and gamma subunits
GPCR Components - ANSWER-More than 800 receptors
7 transmembrane domains
N and C termini
Conformationally flexible
Constitutively active
Receptor tyrosine kinases - ANSWER-Receptor tyrosine kinases (RTKs) consist of an
extracellular ligand
binding and dimerization domain, a single hydrophobic
transmembrane a-helix and a cytosolic domain with intrinsic
tyrosine kinase activity
Two types of RTKs - ANSWER-Single transmembrane spanning proteins that dimerize
when ligand binds (EGF receptor, PGDF receptor)
Covalently linked dimers (insulin receptor, IGF-1 receptor)
PKB/Akt - ANSWER-phosphorylate multiple proteins which regulate a wide variety of
intracellular events
Steroid class receptors - ANSWER-GR, MR, PR, AR, ER
RXR partnered receptors - ANSWER-TR, RAR, VDR, PPAR, a, b, y
Orphan receptors - ANSWER-COUP-TF, HNF-4
Steroid receptor ligands - ANSWER-Steroids
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