100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
N5334 Final Questions And Answers With Complete Solutions $17.99   Add to cart

Exam (elaborations)

N5334 Final Questions And Answers With Complete Solutions

 6 views  0 purchase

N5334 Final Questions And Answers With Complete Solutions

Preview 4 out of 47  pages

  • February 24, 2024
  • 47
  • 2023/2024
  • Exam (elaborations)
  • Questions & answers
All documents for this subject (5)
avatar-seller
Classroom
N5334 Final Questions And Answers With
Complete Solutions
Prescribing basics Correct Answers Prescribing is regulated by
state BON
Proper RX Correct Answers Providers name and address, Telephone
DEA
Pt name/DOB/Addres
Name of Drug, strength, SIG(directions) with indication/Route and frequency, Quantity and signature.
Drug Schedules: Most addictive to least Correct Answers 1: Heroin,LSD, MJ
2: hydrocodone, cocaine, Methamphetamine, methadone, oxycodone, meperidine, fentanyl, adderall, ritalin
3: codeine, ketamine, testosterone
4: xanax, valium, soma, ambient, tramadol
5: antidiarrheal, antitussives, lomotil, lyrica
Pharmicodyamics Correct Answers The effects of drug on the body. Receptors are large molecules usually proteins, that interact and mediate the action of drugs
agonist Correct Answers produce receptor stimulation and a conformational change every time they bind. Do not need all available receptors to produce a maximum response Partial agonist Correct Answers drugs that have properties in b/w those of full agonist and antagonist. They bind to receptors but when they occupy the receptor sites, they stimulate only some of the receptors.
antagonist Correct Answers drugs with affinity for a receptor but with no intrinsic activity. Affinity allows the antagonist to bind to receptors, but lack of intrinsic activity prevents the bound antagonist from causing receptor activation. The block action of drugs (ex. Narcan)
Bioavailabity Correct Answers % of administered dosage of the drug that survives the first pass through the liver and reaches
the blood stream
half life Correct Answers Time required for the amount of a drug in the body to decline by 50%, drugs with shorter half lives
must be administer frequently. 4.5-5.5 times the half life to get steady state and to be limited from the body
what the body does to the drug Correct Answers absorption, distribution, metabolism, excretion
Distribution Correct Answers movement of absorbed drug in bodily fluids throughout the body to target tissue. Properties affecting: lipid/water solubility, PH affects ionization of drug, protein binding, size of molecule (smaller molecules are more able to diffuse)
Tissue: fat, bone, blood/brain barrier (only lipid soluble will pass), placental barrier (many drugs can pass) Protein binding Correct Answers unbound drug is free which is active, crosses membrane. Low plasma proteins result in more
free drug. Competition: when 2 highly bound drugs are given it increases the level of both drugs
Metabolism Correct Answers take place in the liver mostly. Chemical change of a drug structure to: Enhance excretion, inactivate the drug, increase therapeutic action, active a prodrug (inactive until metabolized in the body into the active compound, ex: levodopa), increase or decrease toxicity
CYP450 Correct Answers enzymes constitutes the most important of the phase I metabolizing enzymes (account for about 75% of drug metabolism in the liver)
Phase 2: conjugation reaction occur leading to large increases in hydrophilicity of the substrates rendering them more readily excretable
Substrate Correct Answers an agent that is metabolized by an enzyme into a metabolite and product and eventually excreted
Inhibitors Correct Answers compete with other drugs for a particular enzyme affecting the metabolism (decreased) of the substrate and decreases the excretion of the substrate and increasing the circulating drug
inducer Correct Answers competes with other drugs for a particular enzyme affecting metabolism of the substrate (increases) decreasing the efficacy of the drug excretion Correct Answers renal: passive glomerular filtration,
active tubular secretion, tubular reabsorption, gi tract, lung, sweat and salivary, mammary
genomics Correct Answers study of the complete set of genetic information present in a cell, an organism, or species
pharmacogenetics Correct Answers the study of the influence of hereditary factors on the response of individual organisms to drugs, and the study of variations of DNA and RNA characteristics as related to drug response
Pharmacogenetics tests Correct Answers Mentioned on drug labels can be classified as "test required," "test recommended," and "information only." Currently, four drugs are required to have pharmacogenetics testing performed before they are prescribed: cetuximab, trastuzumab, maraviroc and dasatinib
wafarin, carbamazepine, valproic acid and abacavir are recommended to tests prior to initial dosing
Carbamazepine and Asisans Correct Answers Initiating carbamazepine therapy in these patients (allele HLA-B*1502) are at high risk for developing Steven Johnson syndrome or toxic epidermal necrolysis (TEN)
The ability of the anesthetic to penetrate the axon membrane is determined by 3 properties. What are they? Correct Answers Molecular size, Lipid solubility, degree of ionization at tissue pH

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller Classroom. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $17.99. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

82871 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 14 years now

Start selling
$17.99
  • (0)
  Add to cart