CBT QUESTIONS AND SURE CORRECT ANSWERS 2023/2024
Why would the cancer cells have abnormal proteins that could be presented via MHC? - correct answer Tumors have multiple gene mutations that might be recognized as foreign
If the tumor has such antigens and has presented them to the T cell, ...
if the tumor has such antigens and has presented t
cbt questions and sure correct answers
Written for
CBT
All documents for this subject (377)
Seller
Follow
KieranKent55
Reviews received
Content preview
CBT exam 2
Why would the cancer cells have abnormal proteins that could be presented via MHC? -
correct answer Tumors have multiple gene mutations that might be recognized as
foreign
If the tumor has such antigens and has presented them to the T cell, why hasn't the T
cell responded? - correct answer Tumor cells express PD-L1 which binds to PD-1 and
down regulates the T-cell response
What approach is used in current immunotherapy to bypass the mechanism that tumors
use to block the T-cell response this way? - correct answer Use a PD-1 inhibitor to
disrupt the interaction that keeps the T-cells from responding
What types of side effects are associated with use of immune checkpoint inhibitor
therapies (the answer should be very general? - correct answer Most of the side
effects are related to auto-immunity (rash, fever, etc.)
What is a biomarker? - correct answer a biochemical or genetic feature that can be
used to measure disease progress or the effect of treatment
What are some of the advantages and disadvantages of the use of biomarkers? -
correct answer Advantages: Non-invasive, Possibility of early detection
Disadvantages: False positives, False negatives
Phase 0 - correct answer to determine the pharmacokinetics of the drug (drug lifetime)
Phase I - correct answer to determine the dose of the drug that is toxic, to decide the
maximal dose that should be used in subsequent trials (efficacy might be seen in this
trial, but efficacy testing is not the goal of a Phase I trial
phase II - correct answer to test the drug with a moderate number of patients to
determine its efficacy and side effects
Phase III - correct answer to test the drug with a larger number of patients to
determine its efficacy and gain more information about its safety
Phase IV - correct answer to determine how patients who have been treated with the
drug after it has been approved by the FDA have responded
exosomes - correct answer Small vesicles that are secreted by cells that carry nucleic
acids (especially miRNA and mRNA), some proteins and signaling molecules
Were any of the mechanisms on the following list that are NOT ones that Dr. Kucuk
(and others) have found to be affected by diet in a manner that could affect cancer risk?
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller KieranKent55. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $10.99. You're not tied to anything after your purchase.
