NMTCB PET CERTIFICATION REVIEW 2023 - 2024 QUESTIO
NMTCB PET CERTIFICATION REVIEW 2023 - 2024 QUESTIO
NMTCB PET CERTIFICATION REVIEW 2023 - 2024 QUESTIO
Exam (elaborations)
NMTCB PET CERTIFICATION REVIEW QUESTIONS WITH CORRECT ANSWERS GRADED A
0 view 0 purchase
Course
NMTCB PET CERTIFICATION REVIEW 2023 - 2024 QUESTIO
Institution
NMTCB PET CERTIFICATION REVIEW 2023 - 2024 QUESTIO
NMTCB PET CERTIFICATION REVIEW 2023 -
2024 QUESTIONS WITH CORRECT ANSWERS
GRADED A
NMTCB PET CERTIFICATION REVIEW 2023 -
2024 QUESTIONS WITH CORRECT ANSWERS
GRADED A
NMTCB PET CERTIFICATION REVIEW 2023 -
2024 QUESTIONS WITH CORRECT ANSWERS
GRADED A
NMTCB PET CERTIFICATION REVIEW 2023 -
...
NMTCB PET CERTIFICATION REVIEW 2023 - 2024 QUESTIO
NMTCB PET CERTIFICATION REVIEW 2023 - 2024 QUESTIO
NMTCB PET CERTIFICATION REVIEW 2023 - 2024 QUESTIO
All documents for this subject (1)
Seller
Follow
alkersltzer
Reviews received
Content preview
NMTCB PET CERTIFICATION REVIEW 2023 -
2024 QUESTIONS WITH CORRECT ANSWERS
GRADED A
Rb-82 Genertaor Alert Level - ✔✔14L of eleute volume reached, or Sr-82 level
0.002uCi/mCi of Rb-82, or Sr-85 level 0.02uCi/mCi of Rb-82
Actions for Rb82 Generator Alert Level - ✔✔Test after every 750 mL has passed
through generator
Stop using Rb-82 generator if - ✔✔17L of eleute volume reached, or 42 days
post calibration date, or
Sr82 levenis 0.01uCi/mCi of Rb82, or Sr85 level reaches 0.1uCi/mCi of Rb82
Cyclotron produced isotopes and half-life - ✔✔C11, 20.3 min; N13 9.97 min;
O15 2.03 min; F18, 109.7 min
Advantages of negative ion cyclotrons - ✔✔1) less nuclear activation of cyl
potion cavity and surroundings, 2) can self-focus beam of particles, 3) can
irradiate 2 targets at once
Isotopes produces by negative ion cyclotrons - ✔✔C, N, O = metabolites
Reaction for chemical labeling of F18-FDG - ✔✔Nucleophilic substitution
,NMTCB PET CERTIFICATION REVIEW 2023 -
2024 QUESTIONS WITH CORRECT ANSWERS
GRADED A
Chemical reaction of FDG - ✔✔Electron rich group of atoms change place on
molecule with a positively charged leaving group
Precursor molecule for FDG - ✔✔Mannose triflate
Chem formula of FDG - ✔✔2-deoxy-2-[18F]fluoro-D-glucose. (Fludeoxyglucose
F-18)
Intermediate step in FDG synthesis - ✔✔Alkaline hydrolysis of 4 acetyl groups
by replacing with OH
Size filter used after purification - ✔✔0.22 um
FDA ref for PET pharma production - ✔✔General chapter 823
FDG QA appearance - ✔✔Colorless liquid
FDG QA radiochemical identity - ✔✔Thin-layer chromatography Rf value to
reference standard
,NMTCB PET CERTIFICATION REVIEW 2023 -
2024 QUESTIONS WITH CORRECT ANSWERS
GRADED A
FDG QARadionuclide identity - ✔✔Half-life 105 and 115 minutes
FDG QA bacterial endotoxins test - ✔✔LAL (Limulus amebocyte lysate) <175
USP endotoxins units per max volume injection; endotoxins< 17.5 EU
FDG QC pH - ✔✔Between 4.5 to 7.5
FDG QA Radiochemical purity - ✔✔Thin-layered chromatography radioactive Rf
should be not less than 90% of total radioactivity of chromatography plate
FDG QC Radionuclideic purity - ✔✔should be >99.5% of radionuclidie specified.
tested using multichannel analyzer with peaks at 0.511 and 1.022 MeV
FDG QC chemical purity - ✔✔testing depends upon synthesis method used to
create FDG
Kryptofix 222 - ✔✔FDG QC chemical purity test - thin-layer paper
chromatography spot test. 50 ug/mL and FDG solution must demonstrate a less
intense response than standard
2-Chloro-2-deoxy-D-glucose - ✔✔FDG QC chemical purity test used if hydrolysis
step was performed with hydrochloric acid. Use high-performance liquid
, NMTCB PET CERTIFICATION REVIEW 2023 -
2024 QUESTIONS WITH CORRECT ANSWERS
GRADED A
chromatography using an electrochemical detector. Mus not have more than 1
mg CLDG: 2-deoxy-2-D-glucose
FDG QC Residual solvents - ✔✔solvents can be in FDG from cleaning or
synthesis solutions. solutions may contain acetonitrle, ether anddehydrated
alcohol. no more 0.04% acetonitrle, and less than 0.5% of ether or ethanol
FDG QC Sterility - ✔✔not performed before dosing due to need of 14 days to
perform. Regulations require final produce to be placed in soy broth mixture
with a thioglycollate growth media for 30 hrs. look for observable bacteria
FDG QC Filter membrane integerity - ✔✔final sterility filter used at end of
manufacturing process. Filter must remain intact as pressure increased to 50 psi
(bubble point test)
FDG synthesis room requirements - ✔✔room: cGMP, ISO class 5 clean room air
hood, 21 CFR 212 for manufacturing of IV drugs
which radiouclides are possible radioactive contaminates in eluent of Rb82
generators - ✔✔Sr82 and Dr85
negative ion PET cyclotrons accelerate which partiles - ✔✔negatively charged
hydrogen atoms
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller alkersltzer. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $16.99. You're not tied to anything after your purchase.
