Further
oncology
QUESTIONS
AND
ANSWERS
Why
does
grouping
tumour
types
matter?
Prediction
of
clinical
behaviour
Method
of
metastases
Sarcomas
via
blood
Carcinomas
via
lymphatics
Therapy
Round
cells
need
chemotherapy
Types
of
surgical
excision
Radical
Curative
intent
Marginal
Cytoreductive
Radical
excision
Entire
compartment
or
structure
containing
mass
removed
E.g.
Amputation
Curative
intent
excision
2-3cm
lateral
margins
and
one
facial
plane
(not
fat)
Marginal
excision
Removing
all
the
mass
within
the
pseudocapsule Cytoreductive
excsision
Removing
bulk
of
tumour
within
pseudocapsule
Will
need
further
treatment
Clinical
consequences
of
neoplasia
Functional
issues
Bleeding/ef fusions
Infection
Paraneoplastic
syndromes
Functional
issues
with
neoplasia
Pain
Compression
Obstruction
Bleeding/ef fusions
with
neoplasia
Pleural
effusion
Haemoabdomen
Pericardial
effusion
Infection
with
neoplasia
Opportunistic
invasion
of
necrotic
centre
Paraneoplastic
syndromes
Hypercalcaemia
Cachexia
Hyperviscosity
Hormones
MCTs
*
Histamine
*
Heparin
Hypercalcaemia
Production
of
PTHRP
*
Anal
sac
tumours
*
Lymphomas
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