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UNE Medical Biochemistry Midterm Review – Questions With Complete Solutions
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UNE Medical Biochemistry Midterm Review – Questions With Complete Solutions
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UNE Medical Biochemistry Midterm Review –Questions With Complete Solutions
A family presents for genetic counseling. The couple has two female
children who are alive and well; however, their infant son recently died in
the nursery with severe hemolysis (lysis of red blood cells) and jaundice.
The wife recalls she lost a brother in infancy with severe hemolysis,
induced after a viral infection. The physician suspects a glucose-6-
phosphate dehydrogenase deficiency, this would result in a deficiency in
which of the following compounds in red blood cells? Correct Ans -
Ribose and NADPH
A patient presents to the emergency department with lactic acidosis. A
deficiency in thiamine (TPP) is suspected and this will be consistent with a
decrease in the activity of following enzymes? Correct Ans -
Transketolase
Galactose 1-phosphate is initially converted to glucose 1-phosphate and
requires which of the following compounds? Correct Ans - UDP-
Glucose
Which of the following cofactors is required for transketolase activity?
Correct Ans - Thiamine diphosphate
Aldolase B facilities a reaction that cleaves fructose 1-phosphate into two
3-carbon molecules that will enter glycolysis as which of the following
compounds? Correct Ans - Glyceraldehyde 3-phosphate
High levels of activity of the non-oxidative portion of the pentose
phosphate pathway will directly produce intermediates of which of the
following pathways? Correct Ans - Glycolysis
The major regulatory step of the pentose phosphate pathway is catalyzed
by which enzyme? Correct Ans - Glucose 6-phosphate
dehydrogenase
, Insulin stimulates fatty acid synthesis in the liver. These fatty acids are
transported to the adipose tissue as which of the following? Correct
Ans - VLDL particles
A young woman goes to work without eating breakfast and skips lunch. In
this scenario, which of the following pathways is providing substrates used
to generate ATP in the liver? Correct Ans - Free fatty acids
Caffeine is a natural inhibitor of phosphodiesterase. If you were to consume
a large amount of coffee you would likely see a prolonged response to
which of the following stimulants or hormones? Correct Ans -
Glucagon
A teenage female presenting with lack of menstruation (amenorrhea) is
found to have a dysfunctional steroid receptor characteristic of androgen
insensitivity syndrome. Which of the following statements accurately
describes steroid hormones? Correct Ans - They enhance
transcription when bound to receptors
Steroid hormones bind which of the following types of receptors?
Correct Ans - Intracellular receptors
Which of the following is a characteristic of all receptors? Correct Ans
- They are specific to a chemical messenger
What is the primary oxidized fuel for skeletal muscle in the fasted state?
Correct Ans - Free fatty acids
cAMP elicits multiple cellular responses. The effects of cAMP on gene
transcription are directly mediated by which of the following DNA binding
proteins? Correct Ans - Cyclic-AMP response element binding
protein (CREB)
An individual is recently diagnosed with Type 2 diabetes. In this individual,
hyperglycemia may in part be due to inactivity of which of the following
glucose transporters on skeletal muscle? Correct Ans - GLUT4
Glycogen degradation in the liver can be enhanced by elevated glucagon
and the activation of a G αs receptor. The initial step in this cascade involves
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