Exam (elaborations)
ASCP Hematology 2024/2025 already graded A+
- Course
- Institution
ASCP Hematology 2024/2025 already graded A+
[Show more]
Content preview
ASCP HematologyDohle bodies - ANSLight blue patches in cytoplasm of neutrophils. Infection, burns
Erythrocytes - ANSO2 transport. Produced in BM
Mean Corpuscular Hemoglobin (MCH) formula - ANS(HGBx10)/RBC
Mean Corpuscular Hemoglobin Concentration (MCHC) formulao - ANS(HGBx100)/HCT
Granulocytes - ANSDefense against bacterial infection. Produced in BM
Lymphocytes - ANSCellular and humoral immunity. Produced in lymphoid tissue
Platelets - ANSCoagulation. Produced in BM
WBC RR - ANS4.5-11.5 x10^3 / microL
RBC RR - ANSM: 4.6-6x10^6 / microL
F: 4-5.4x10^ / microL
HGB RR - ANSM: 14-18 g/dL
F: 12-15 g/dL
HCT RR - ANSM: 40-54%
F: 35-49%
MCV RR - ANS80-100 fL
MCH RR - ANS27-31 pg
MCHC RR - ANS32-36%
PLT RR - ANS150-450x10^3 microL
MCV first 5 days - ANSMacrocytes. Higher in preterm infants
Retic % - ANSnewborns increased polychromasia
Seg % - ANS50-70
Band % - ANS0-5
,Lymph newborn - ANSfew benign immature B cells may be seen
common myeloid progenitor - ANSdifferentiate into erythrocytes, platelets (megaK),
granulocytes (basophils, eosinophil, neutrophil), and monocytes
common lymphoid progenitor (CLP) - ANST-lymph, NK cell, B-lymph
Multipotential progenitor cell - ANSCommon myeloid progenitor or common lymphoid progenitor
Erytheopoiesis 1-2 month gestation - ANSyolk sac and aorta-gonads mesonephros region
(gower I/II and portland)
Erythropoiesis 3-6 month gestation - ANSliver (primary), spleen
Erythropoiesis 7 month of gestation-4 years - ANSBone marrow (all marrow active)
Erythropoiesis adult - ANSbone marrow (pelvis, vertebrae, ribs, sternum, skull. Shafts of long
bones filled with fat-may reactivate to compensate for anemia- liver and spleen may reactivate if
that fails to keep up with demand)
Rubriblast/pronormoblast - ANS14-24 um
N:C ratio 8:1
Royal blue cytoplasm. Fine chromatin
1-2 nucleoli
Normally confined to bone marrow.
Prorubricyte/basophilic normoblast - ANS12-17 um
N:C ratio 6:1
Chromatin is coarser with slightly visible parachromatin
Nucleoli not visible
Normally confined to bone marrow.
Rubricyte/polychromatophilic normoblast - ANS10-15 um. N:C ratio 4:1. Cytoplasm is
polychromatophilic due to hemoglobin production. Chromatin is clumped with distinct areas of
parachromatin. Last stage to divide. Normally confined to bone marrow.
Metarubricyte/orthochromic normoblast - ANS8-12 um
N:C ratio 1:2
Nucleus is pyknotic
Last nucleated stage
Normally confined to bone marrow.
Reticulocyte/Polychromatophilic erythrocyte - ANS7-10 um
, No nucleus. Cytoplasm is diffusely basophilic (bluish tinge)
Reticulum seen with supravital stain. 0.5%-1.5% of RBCs in adult peripheral blood.
Mature erythrocyte - ANS7-8 um
Biconcave disk. Reddish-pink cytoplasm with area of central pallor 1/3 diameter of cell.
Megaloblastic anemia cause - ANSvitamin b12 or folic acid deficiency (ex pernicious anemia)
Megaloblastic characteristics - ANSNucleus lags behind cytoplasm in maturation. cells grow
larger without dividing. Oval macrocytes
Iron deficiency characteristics - ANScytoplasm lags behind nucleus in maturation due to
inadequate iron for hgb synthesis. Microcytic, hypochromic RBCs
Hemoglobin A - ANS2 alpha + 2 beta, >95% adults, 20% newborn
Hemoglobin A2 - ANS2 alpha + 2 delta, 1.5-3.7% adults, <1% newborns
Hemoglobin F - ANS2 alpha + 2 gamma, <2% adults, 50-85% newborn
Hemoglobin S - ANSValine substituted for glutamic acid in 6th position of beta chain
Hemoglobin C - ANSLysine substituted for glutamic acid in 6th position of beta chain
Cellulose Acetate pH 8.6 crawl (closet to cathode - and origin) - ANShbg A2, C, E, OArab,
CHarlem (A2,CE, Of, Clubs(harlem))
Cellulose Acetate pH 8.6 slow - ANShgb S, D, G, Lepore (Sad, Dog, Gets, Loved)
Cellulose Acetate pH 8.6 fast - ANShgb F
Cellulose Acetate pH 8.6 accelerated (closest to anode +) - ANShgb A
Citrate agar pH 6.2 - ANScathode, F, A/A2, origin, S, C, anode
Methemoglobin - ANSiron oxidized to ferric (3+), usually acquired from exposure to oxidants,
cant bind O2, cyanosis, possibly death.
Methemoglobin findings - ANSHeinz bodies. treat with methylene blue
Sulfhemoglobin - ANSSulfur bound to heme. Acquired from exposure to drugs & chemicals. O2
affinity 1/100th normal. Cyanosis. Cant be converted back to normal hemoglobin
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Ashley96. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $9.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
78140 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now