I passed this course with an 8.5
Also, check out the neurodegenerative diseases summary with all the study material on that part of the course.
This overview contains (psychiatric diseases):
-symptoms
-prevalence
- Heritability
- Brain area's
- Genes
- Environmental factors
- treatmen...
ADHD Depression Schizophrenia An3social and criminal behaviour
-a disorder of brain - Depressed or irritable mood Posi3ve symptoms An3social personality disorder:
matura3on delay - Anhedoniaà less pleasure - Psychosis (delusions and - Apparent lack of remorse
- Significant weight loss hallucina3on) - Aggressive, oWen violent
- Ina7en3on - Insomnia or hypersomnia - Disorganized speech behaviour
- Hyperac3ve - Psychomotor agita3on or - Distor3ons/exaggera3ons in - Inability to tolerate boredom
- Impulsivity retarda3on language + communica3on - Lack of access to own feelings
BUT ALSO - Fa3gue or loss of energy - disorganized behaviour and emo3ons
- Spontaneous - Feeling of worthlessness or - agita3on - Severe disrup3on in moral
- Crea3ve execu3ve guilt Nega3ve symptoms behaviour
- Divergent mind - Diminished ability to think or - blunted affect
- Vital concentrate - dysfunc3on of mo3va3on Subtypes
- High energy - Recurrent thoughts of death or - Anhedonia Psychopathy
- Fast thinking suicide - A-sociality - Callousness, manipula3veness,
Cogni3ve symptoms superficial charm
- A7en3onal problems - OWen highly intelligent
- Execu3ve dysfunc3on (PFC) - Grandiose sense of self-worth
(megalomania)
- Have ability but a reduced
Delusion= misinterpreta3on propensity for empathy
Hallucina3on= too much sensory input Conduct disorder: children ASPD
Prevalence 2-5% children age 6-16 10-20% will experience depression in 1% of populaAon More prevalent in male sex
their life (testosterone)
80% boys Onset in adolescence (15-25)
Twice as much females - Due to no LTP as NMDA-R
Symptoms persist into hypofuncAon
adulthood in 30-50% of Netherlands: 5%=800.000 adults and - More synapse pruning (starAng
cases 160.000 chronic in adolescence)
Co-morbidity with addicAon Co-morbidity with anxiety, ADHD, Concordance rate dizygoAc twins 17%
addicAon and other psychiatric diseases Concordance rate monozygoAc twins:
48%
Heritability ADHD: 75% Less severe depression: 25% Schizophrenia: 80% ASPD: 40-50%
AuAsm: 80% Major/chronic depression: 40-50% Personality: 50%
Bipolar:80%
, Brain area’s ¯PFC ¯PFC (BUT no performance deficit) ¯NMDA-receptor Decrease in moral judgement tasks
¯Cerebellum Amygdala ¯corAco-brainstem projecAon - PFC
¯Caudate nucleus (possibly normally: PFC inhibits (glutamate) - Amygdala
¯Corpus callosum amygdala) - Less tonic excitaAon of - cingulate
¯Amygdala ¯Hippocampus mesocorAcal pathway - Angular gyrus
¯Accumbens - Tail and headà risk - Less GABA release from Increase rule breaking behaviour
¯Hippocampus - Bodyà current state interneuron and thus Less tonic - PFC
¯Basal ganglia HPA axis inhibiAon of the mesolimbic - Amygdala
- Subtype: insomnia, loss of pathway - Angular gyrus
appeAte, weight loss and. Loss Mesolimbic dopamine These areas are probably ¯
of libido - Too much dopamine in ventral
- Increased corAsol and CRH striatum ¯PFC
- Reduced glucocorAcoid - PosiAve symptoms ¯Amygdala
receptors hippocampus and ¯MesocorAcal dopamine ¯Hippocampus
hypothalamus - Too liale dopamine in PFC Angular gyrus
¯BDNF - NegaAve and cogniAve Cingulate
- PFC and hippocampus symptoms Temporal cortex
Cytokines ¯GABA in thalamus
- Interleukin-6 and TNFa - Excess dopamine from the Failure of fear condiAoning
- Subtype: hypersomnia and meso-limbic pathway inhibits - Causal role for crime
weight gain GABA striatal-thalamic neuron - Amygdala dysfuncAon
DisrupAon chronobiological model - NMDA-R hypofuncAon causes
- early awake hypofuncAon of the corAco- Cavum septum pellucidum
Bacterial species striatal pathway and less - Marker for fetal limbic
- ¯Bacterial species that secrete acAvaAon of GABA striatal- maldevelopment
anA-inflammatory cytokines thalamic neuron - Significantly higher probability
- Bacterial species that secret - Less filtering> sensory overload of anA-social personality,
pro-inflammatory cytokines psychopathy, criminal charges
Default mode network and convicAons
- HyperconnecAvity
- More introspecAon and self-
referenAal thinking
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller lvd26. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $6.78. You're not tied to anything after your purchase.
