Aprepitant (Emend) - answershighly selective oral P Neurokinin1 (NKI) receptor antagonist. Prevention
of CINV in combo with standard antiemetic regimens
Fosaprepitant - answersIV drug converted to Aprepitant in 30 min
Amiodarone & Fluoroquinolones (prolong QT) - answersavoid these drugs with serotonin receptor
antagonist antiemetics
Decadron - answersenhance the efficacy of 5-HT3 (serotonin) receptor antagonists for CINV (short term
use)
PPI BID, Clarithromycin, Amoxicillin or Metronidazole - answers1st line therapy for H. Pylori
Calcium carbonate (TUMS) - answersantacids that can cause kidney stones & constipation
magnesium hydroxide & H2 antagonists - answersAssess for renal insufficiency with these antacids
, Cimetidine (Tagamet) - answersH2 antagonist with CYP interactions
PPI's - answersirreversibly binds to enzyme H, K-ATPase to inhibit the proton pump
Clopidogrel (Plavix) - answersOmeprazole inhibits CYP 2C19 which my inhibit metabolism of --
Misoprostol (Cytotec) - answersAVOID this if pregnant! inhibits gastric production & stimulates
production of mucous
-psyllium
-methycellulose - answersBulk laxatives: MUST take with water
-promotes peristalsis
Mg Hydroxide or Mg Citrate - answersosmotic laxative: avoid in renal patients
Torsades de pointe - answersMajor risk with Loperamide (Imodium)
-Linaclotide (Linzess)
-Lubiprostone (Amitiza)- women only
-PEG laxatives - answersDrugs used if IBS with constipation
Linaclotide (Linzess) - answersDrug used of IBS with constipation that increases intestinal fluid so stool
softens
-Mesalamine PR
-Hydrocortisone PR - answersTreatment of mild/moderate U.C.
Zetia - answerscholesterol absorption inhibitor, acts as brush boarder for small intestine
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