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APHON Principles Of Biotherapy – Questions With Complete Solutions
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APHON Principles Of Biotherapy – Questions With Complete Solutions
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APHON Principles Of Biotherapy – Questions WithComplete Solutions
Biotherapy ✔️Ans - modality of tx: agents that resemble body's own defense
and surveillance systems. can augment/modulate/restore host's immune
response, direct antitumor activity, other biological effects. side effects
typically hypersensitivity rx
Immune surveillance ✔️Ans - tumor cells express abnormal tumor antigens
on surface that can be recognized/destroyed by immune system
Natural killer cells ✔️Ans - lymphocyte that recognizes/kills malignant cells
Cytotoxic t cells ✔️Ans - recognize tumor-assosiated antigens and kills cells
interferons ✔️Ans - multiple moa's & produced w/ recombinant dna.
protein capable of protecting other cells from viral infections by interfering
w/ viral replication.
family of glycoproteins include: antiviral, antiproliferative, potent
immunomodulatory effects
cytokines ✔️Ans - products of immune cells to enhance cytotoxic activity of
cells and increase immune response
alpha-interferon ✔️Ans - leukocyte-derived. tx: hairy cell leukemia,
melanoma, chronic myeloid leukemia, follicular lymphoma, multiple myeloma,
cutaneous t-cell lymphoma
beta-interferon ✔️Ans - fibroblast-derived. tx MS
gamma-interferon ✔️Ans - t-lymphocyte derived. tx chronic granulomatus
disease
interleukin-2 ✔️Ans - produced by t-helper cells & stimulate
growth/maturation of t-cell subsets, cytotoxic t-cells, production of
lymphokines & cytokines.
act as chemical signals b/w wbc's (revs up immune system)
, retinoids ✔️Ans - immunomodulators that facilitate differentiation &
suppress proliferation of cancer cells
all-trans retinoic acid (atra) ✔️Ans - tx: aml, aml m3 subtype, apl
increase maturation of promyelocytic blasts and rapid resolution of
coagulopathy r/t tx.
isotretinoin (accutane) ✔️Ans - retinoid tx neuroblastoma.
have antitumor activity unknown moa. TERATOGENIC. male/female pt must
register iPledge (fetal exposure). can also affect hearing & vision
antibodies ✔️Ans - proteins produced by b-lymphocytes. part of humoral
immunity of adaptive system. includes immunoglobulins (igG, igA, igM, igE,
igD)
murine ✔️Ans - mouse-derived MoAbs. pt develops human antimouse
antibodies creating high risk of hypersensitivity rx
end in -momab
Monoclonal antibodies ✔️Ans - very specific. directed against single
antigenic determinant on cell surface causing antibody-dependent cellular
toxicity, direct cell death, elimination of antigen/target cell that expresses the
antigen
low toxicity
-ximab ✔️Ans - moab combo of human & mouse antibodies
-zumab ✔️Ans - moab humanized, small part of mouse antibody fused w/
human antibody
-umab ✔️Ans - fully humanized moabs
chimeric moab ✔️Ans - murine variable & human constant coupled using
recombinant dna
purpose of moabs ✔️Ans - attach low-dose radioisotopes to image residual
disease. target chemo, radiation, biotherapy to tumor
purge autologous bone marrow of cancer cells before transplant
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