Exam (elaborations)
Sample Final exam answers: Intro to Biopharmaceutical Science
- Course
- Institution
Sample Final exam answers Intro to Biopharmaceutical Science BPS 2110 (Professor William Ogilvie)
[Show more]
Seller
Follow
elgoussimaamoun073
Content preview
Complete the following table describing the stages of drug development. (9 points)Use a diagram to describe the way that a non-competitive inhibitor works. (5 Points)
A non-competitive inhibitor binds to a different location on the enzyme than the substrate does.
Inhibitor binding prevents formation of the ES complex. This type of inhibitor alters kcat and
Vmax but does not affect Km
H-Bond donors: 4 H-Bond acceptor: 8 ⇒ No violation of Lipinsky’s rules, likely bioavailable.
, H-Bond donors: 6 H-Bond acceptor: 11 ⇒ 4 violations of Lipinsky’s rule: LogP is above 5,
MW is over 500 and number of hydrogen bond acceptors is more than 10 and acceptors over 5,
therefore the drug is unlikely to be bioavailable.
The following molecule was once considered as a drug candidate by a large
pharmaceutical company. The acid-base behavior of each of the functional groups is
indicated.
a) Write the pKa expression for the first functional group and identify an appropriate pKa value
using the table provided. (3 Points)
b) Write the pKa expression for the second functional group and identify an appropriate pKa
value using the table provided. (3 Points)
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller elgoussimaamoun073. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $25.49. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
83100 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now