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BPS 2110 Intro to Biopharm Mid Term 2 Answers
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BPS 2110 Intro to Biopharm Mid Term 2 Answers (Corrected)
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BPS 2110 Intro to BiopharmMid Term 2 Answers
1) Complete the following table describing pathogen classification. (4 Points)
Example organism
Class 1
E. coli
Class 2
Herpes
Class 3
HIV
COVID
Y. Pestis
Class 4
Ebola
Marburg
Lassa fever
Hanta virus
Smallpox
2) This structure is the basis of most modern antibiotics.
H
N S
O N
O
CO2H
a) What enzyme does it inhibit? (1 Point)
transpeptidase
b) What functional group structure in the molecule shown above is responsible for enzyme
inhibition (name and structure)? (2 Points)
c) Use a mechanism to show how this feature reacts with the enzyme to produce inhibition (5
Points)
1
, d) This class of drug is easily damaged by low pH conditions. Provide a mechanism to explain
why this is. (6 Points)
e) Suggest one structural modification that could be made to the drug to make it more resistant
to acid, and briefly explain how the change will work. (2 Points)
Add EWG to left side of molecule
Removes electrons from the nearby C=O making it a poor nucleophile
3) Enzymes are catalysts that carry out reactions in living things.
a) Use a reaction co-ordinate diagram to explain how enzymes are able to catalyze reactions
(4 Points)
Enzymes bind tightly to transition states and lower the energy of the transition state
This lowers the activation energy for the reaction
2
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