Exam (elaborations)
Day 5 NP: Multiple Sclerosis Questions With Complete Solutions
- Course
- Institution
Day 5 NP: Multiple Sclerosis Questions With Complete Solutions
[Show more]
Seller
Follow
Classroom
Reviews received
Content preview
Day 5 NP: Multiple Sclerosis Questions WithComplete Solutions
Myelin =
- cellular structure w/unique lipid & protein composition
- insulates neurons & forms nodes
Action potentials travel rapidly:
from node to node (Nodes of Ranvier - the depolarized region of
the membrane)
What is node to node travel called?
Saltatory Neurotransmission (think sodium)
Myelin Sheaths _____ speed of AP down axon
Increase
Myelinated vs. Demyelinated - image
,MS =
- Multiple: affects numerous areas of the brain, optic nerves, &
spinal cord
- Sclerosis: characteristic plaques or sclerosed areas (hallmark)
- Disease of CNS - PNS not involved
Is there a cure for MS?
No - no known cause either
T/F: MS is the most common chronic disease affecting the CNS
in young adults
TRUE
Is MS more prevalent in men or women?
Women (2-3x more than men)
MS symptoms usually begin at what age?
20-40 y/o
,MS is more common in what geographical location?
- North of equator
- 2x as prevalent in northern states
Geographical location in mind, what Vitamin may play a role in
MS development?
Vitamin D
MS is more common among what race?
Caucasians
(lowest in Asians)
Viral etiology
- Direct attack on myelin and/or oligodendrocyte
- Produces antigens similar to human proteins (MBP) -
molecular mimicry
- Stimulation of autoimmune response --> demyelination
Genetic factors?
Likely, but no genes ID'd - likely multiple genes involved
- Monozygotic twins >>> Dizygotic (non-identical) twins
- higher incidence w/parent w/MS
Why some & not others?
- Some alleles of MHC may be better at displaying self-antigens
- genetic predisposition
, - environmental exposure
- migration studies suggest early life exposure
More favorable prognosis when:
- Age of onset: <40 y/o
- Gender: Female
- Initial symptom: optic neuritis or sensory symptoms (Less
favorable w/motor or cerebellar symptoms)
- Low attack frequency in early disease
- Lower # of lesions on MRI
- Relapsing/Remitting course of disease (vs. progressive)
MS is a:
- Generally progressive autoimmune-mediated inflammatory
disease of the CNS characterized by areas of demyelination in
the brain, optic nerve tracts, & spinal cord
- Lesions result in multiple & varied neuro symptoms
MS symptoms
- Sensory symptoms
- Weakness & clumsiness
- Visual disturbances
- Bowel & bladder dysfunction
- Stiffness & gait disturbances
- Mental & cognitive disturbances
MS Pathophysiology - Autoimmune theory
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Classroom. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $11.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
79373 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now