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AAB MT Hematology |232 questions with 100% correct answers
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AAB MT Hematology |232 questions with 100% correct answers
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AAB MT Hematology 232 questions with100% correct answers
What is hemoglobin composed of? - answer 4 heme, 4 iron, 4 globins
What disorder does a defect in heme synthesis lead to? - answer Porphyria
Porphyria - answer Deficiency in the enzymes of the porphyrin pathway leads to insufficient
production of heme. The principal problem in these deficiencies is the accumulation of
porphyrins, the heme precursors, which are toxic to tissue in high concentrations.
What is methemoglobin? - answer Methemoglobin is a form of hemoglobin that contains ferric
[Fe3+] iron and has a decreased ability to bind oxygen. However, the ferric iron has an increased
affinity for bound oxygen. When methemoglobin concentration is elevated in red blood cells,
tissue hypoxia can occur.
What is the function of the enzyme methemoglobin-cytochrome C reductase in a red blood
cell? - answer To keep iron in the ferrous state
What product is formed when ferrous iron of hemoglobin is oxidized to the ferric state? -
answer Methemoglobin
What is carboxyhemoglobin? - answer A stable complex of carbon monoxide and hemoglobin
that forms in RBCs when carbon monoxide is inhaled or produced in normal metabolism. Large
quantities of it hinder delivery of O2 to the body. Tobacco smoking (through carbon monoxide
inhalation) raises the blood levels of COHb by a factor of several times from its normal
concentrations.
Which hemoglobin has a 200 times greater binding capacity for the hemoglobin molecule than
oxygen? - answer Carboxyhemoglobin
,Which hemoglobin derivative causes irreversible changes in RBCs? - answer Sulfhemoglobin --
makes blood incapable of carrying oxygen.
Which of the following hemoglobins is NOT normally present in a normal adult? - answer Hb-S
Which embryonic hemoglobin is normally found in newborns? - answer Hb-F
What is the most abundant hemoglobin in a newborn? - answer Hb-F
What is the molecular structure of Hemoglobin S? - answer Valine replaces glutamic acid in the
6th position of the beta chain
Which of the following hemoglobins is insoluble under lowered oxygen tension? - answer Hb-S
What laboratory test is used to confirm the specific diagnosis of sickle cell anemia? - answer
Hemoglobin electrophoresis
In the solubility test for hemoglobin S, what is the reagent responsible for the reduction of the
hemoglobin molecule? - answer Sodium dithionite
In hemoglobin C, what replaces glutamic acid? - answer Lysine
Which red blood cell inclusion is characteristic of hemoglobin C disease? - answer Rod-shaped
crystals
What is hemoglobin F composed of? - answer 2 alpha and 2 gamma chains
Which hemoglobin is resistant to alkali denaturation? - answer Hb-F
, Which hemoglobins are differentiated by the Kleihauer-Betke technique? - answer Hb-A1 from
Hb-F
What is the order of migration of hemoglobins, from fastest to slowest, on cellulose acetate at
pH 8.4? - answer A1, F, S, C
Why is citrate agar used when abnormal hemoglobins are identified on cellulose acetate at pH
8.6? - answer It separates hemoglobin S from hemoglobin D
The cyanmethemoglobin method measures all hemoglobin pigments EXCEPT which one? -
answer Sulfhemoglobin
What is the diluent used in the cyanmethemoglobin method for the determination of
hemoglobin? - answer Drabkin's solution
What is the normal plasma hemoglobin concentration? - answer 2-3 mg/dL
Which plasma protein binds free hemoglobin? - answer Haptoglobin
Which one of the following statements concerning hemolytic anemia is false? - answer The
serum haptoglobin is increased
In this type of anemia RBCs are normocytic and normochromic. RBCs, hemoglobin, and
hematocrit are decreased and the indirect bilirubin is increased. - answer Hemolytic anemia
Myoglobin can be separated from hemoglobin by saturating the specimen with which one of
the following reagents? - answer Ammonium sulfite
The hematocrit is also known as which one of the following terms? - answer Packed red blood
cell volume
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