The process by which the body break down and coverts a medication into active subtance is know as metabolism The term NOT associated with the pharmacokinetics of a drug is Pharmacodynamics R ationale: Pharmacokinetics can be simply described as the study of 'what the body does to the drugs' and inc...
NUR 635 Advanced Pharmacology Mid -Term Exam (Correctly answered with Rationales) The process by which the body break down and coverts a medication into active subtance is know as metabolism The term NOT associated with the pharmacokinetics of a drug is Pharmacodynamics Rationale: Pharmacokinetics can be simply described as the study of 'what the body does to the drugs' and includes: the rate and extend to which drugs are absorbed and distributed to body tissue; the rate and pathways by which drugs are eliminated from the body by metabolism and excretion; and the relationship between time and plasma drug concentration. It includes the processes of absorption, distribution, metabolism, and excretion. Pharmacodynamics is the effect that a drug has on the body. Terms associat ed with pharmacodynamics include receptors (i.e. affinity), drug potency (i.e. amount of drug required to produce a therapeutic response), and drug response cure (i.e. effective dose, toxic dose, therapeutic index). The elimination phase of pharmacokinetics is the time it takes for the plasma concentration of a drug to decrease by 50% Rationale: The elimination phase or elimination half -life is the time required for a drug to reach half (50%) of its state in the serum. The pharmacokinetics of a drug may be affected by Compliance by the patient. Rationale: Factors that affect the pharmacokinetics (what the body does to the drug) of a drug include: compliance by the patient; dosing and medication error; absorption; tissue and body fluid; mass and volume; drug interaction; elimination and drug metab olism. Pharmacokinetics will be variable if the drug does not reach the body or doesn't stay in the body long enough. Pharmacodynamics (what the drug does to the body) is affected by drug receptors, genetic factors, drug interaction, and tolerance. In the pharmacokinetics of a drug, the rate of metabolism: varies widely among patients. Rationale: Metabolism is the process by which drugs are chemically changed from a lipid -soluble from suitable for absorption and distribution to a more water -
soluble form that is suitable for excretion. The rate of drug metabolism varies widely among patie nts, influenced by genetic and environmental factors. This is the major reason for differences in the plasma concentration of some drugs after a standard dose, leading to wide variation in drug response. The type of study that defines the mayor metabolites concentrations in serum and other body compartment is: Pharmacokinetics Studies
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