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Exam (elaborations)

ASCP Hematology Review Exam Questions & Answers 2023/2024

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ASCP Hematology Review Exam Questions & Answers 2023/2024 Name the locations of active marrow in adults: - ANSWER-sternum, skull, ribs, pelvis, vertebrae Where does hematopoiesis take place during the first 2 months of gestation? - ANSWER-yolk sac Where does the majority of hematopoiesis...

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  • September 7, 2023
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  • 2023/2024
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  • ASCP Hematology
  • ASCP Hematology
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ASCP Hematology Review Exam
Questions & Answers 2023/2024

Name the locations of active marrow in adults: - ANSWER-sternum, skull, ribs, pelvis, vertebrae



Where does hematopoiesis take place during the first 2 months of gestation? - ANSWER-yolk sac



Where does the majority of hematopoiesis take place during the 2nd through 7th month of gestation? -
ANSWER-spleen



When does the bone marrow take over hematopoiesis? - ANSWER-after birth



What are the stages in order of the erythrocyte lineage? - ANSWER-(1)rubriblast, (2)prorubricyte,
(3)rubricyte, (4)metarubricyte, (5)reticulocyte, (6)erytrocyte



What are the stages in order of the granulocyte (neutrophil, eosinophil, basophil) lineage? - ANSWER-
(1)myeloblast, (2)promyelocyte, (3)myelocyte, (4)metamyelocyte, (5)band, (6)segmented (7)eos/baso



What are the stages in order of the macrophage lineage? - ANSWER-(1)monoblast, (2)promonocyte,
(3)monocyte, (4)macrophage



What are the stages in order of the platelet lineage? - ANSWER-(1)megakaryoblast,
(2)promegakaryocyte, (3)megakaryocyte, (4)platelet



What are the stages in order of the lymphocyte lineage? - ANSWER-(1)lymphoblast, (2)prolymphocyte,
(3)lymphocyte



Which growth factors stimulate the erythrocyte lineage? - ANSWER-GM-CSF, EPO, IL-3

,Which growth factors stimulate the granulocyte lineages? - ANSWER-GM-CSF, IL-3



Which growth factors stimulate the platelet lineage? - ANSWER-GM-CSF, IL-3, TPO



Which growth factors stimulate the lymphocyte lineage? - ANSWER-IL-2, IL-4, IL-6, IL-7



Which protein functions in the transport of Fe? - ANSWER-transferrin



What is the major storage form of Fe? - ANSWER-ferritin



What is the long-term (H20) insoluble Fe storage form called? - ANSWER-hemosiderin



Excess Iron is stored where? What does this cause? - ANSWER-tissues and body organs, hemosiderosis,
hemochromatosis



Porphyrias are attributed to? - ANSWER-excessive formation of porphrins due to blockages in any
enzymatic step in the heme synthesis pathway.



Red or port wine colored urine can be seen in which condition related to the build up of heme
precursors? - ANSWER-porphyria



Neuropsychiatirc symptoms are seen when a build up of which precursors occurs? - ANSWER-early
precursors (Delta-aminolevulinic acid/Porphobilinogen)



Cutaneous symptoms such as photo-sensitivity and facial hair are seen when a build up of which
precursors occurs? - ANSWER-later precursors (uroporphyrinogen/coproporphyrinogen,
protoporphyrin/heme)



Synthesis of heme requires what two components? - ANSWER-iron, protoporphyrin

, What are the heme precursors in order of synthesis? - ANSWER-(1)delta-aminolevulinic acid,
(2)porphobilinogen, (3)uroporphyrinogen, (4)coproporphyrinogen, (5)protoporphyrin, (6)heme



What type of hemoglobin is seen primarily in newborns? - ANSWER-Hgb F



What type of hemoglobin is seen primarily in adults? - ANSWER-Hgb A2



What type of hemoglobin is rarely seen in adults as well as newborns? - ANSWER-Hgb A



What hemoglobin types are seen in embryos but not in adults or newborns? - ANSWER-gower I, gower
II, portland



All non-embryonic hemoglobin types are comprised of what type of globin chain? - ANSWER-alpha



Hemoglobin A2 is composed of what types of globin chains? - ANSWER-alpha, beta



Hemoglobin A is composed of what types of globin chains? - ANSWER-alpha, delta



Hemoglobin F is composed of what types of globin chains? - ANSWER-alpha, gamma



Multiple transfusions can cause what kind of shift in the hemoglobin-oxygen dissociation curve? -
ANSWER-left shift



An increase in hemoglobin F can cause what kind of shift in the hemoglobin-oxygen dissociation curve? -
ANSWER-left shift



A left shift in the hemoglobin-oxygen dissociation curve causes what changes in the following
substances: CO2, pH, 2,3-DPG? - ANSWER-increased pH, decreased CO2, decreased 2,3-DPG



A right shift in the hemoglobin-oxygen dissociation curve causes what changes in the following
substances: CO2, pH, 2,3-DPG? - ANSWER-decreased pH, increased CO2, increased 2,3-DPG

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