Chapter 06 Epigenetics and Disease TEST BANK PATHOPHYSIOLOGY THE BIOLOGIC BASIS FOR DISEASE IN ADULTS AND CHILDREN
3 views 0 purchase
Course
PATHOPHYSIOLOGY
Institution
PATHOPHYSIOLOGY
MULTIPLE CHOICE
1. What genetic process is likely responsible for the occurrence of asthma in only one of a pair of identical twins?
a. Epigenetic modifications
b. Genomic imprinting
c. Transgenerational inheritance
d. Methylation
ANS: A
Epigenetic modifications can cause indivi...
Test Bank - Pathophysiology: The Biologic Basis for Disease in Adults and Children (8th Edition)
, Test Bank - Pathophysiology: The Biologic Basis for Disease in Adults and Children (8th Edition)
MULTIPLE CHOICE
1. What genetic process is likely responsible for the occurrence of asthma in only one of a pair of identical
twins?
a. Epigenetic modifications
b. Genomic imprinting
c. Transgenerational inheritance
d. Methylation
ANS: A
Epigenetic modifications can cause individuals with the same deoxyribonucleic acid (DNA)
sequences (such as identical twins) to have different disease profiles. Imprinting means that either the
copy of a gene inherited through the sperm or the copy inherited through the egg is inactivated and
remains in this inactive state in all of the somatic cells of the individual. The heritable transmission to
future generations of epigenetic modifications is called transgenerational inheritance. DNA
methylation occurs through the attachment of a methyl group to the carbon-5 position of a cytosine.
PTS: 1 DIF: Cognitive Level: Remembering
2. Prader-Willi syndrome causes a chromosomal defect that is what?
a. Initiated by postnatal exposure to a virus
b. Inherited from the father
c. Related to maternal alcohol abuse
d. Transferred from mother to child
ANS: B
Prader-Willi syndrome can be caused by a 4 Mb deletion of chromosome 15q when inherited from the
father. This disorder is not caused by a virus, or related to maternal alcohol abuse. The same gene
deletion causes Angelman syndrome when inherited from the mother.
PTS: 1 DIF: Cognitive Level: Remembering
3. What can a malfunction in DNA methylation lead to?
a. Hypothyroidism
b. Blindness
c. Cancer
d. Diabetes mellitus
ANS: C
Aberrant methylation can lead to silencing of tumor-suppressor genes in the development of cancer.
No research supports a connection between hypothyroidism, blindness, or diabetes mellitus to a
malfunctioning of DNA methylation.
PTS: 1 DIF: Cognitive Level: Remembering
4. Which statement is true regarding the embryonic development of stem cells?
a. They are already differentiated.
b. They are referred to as housekeeping genes.
c. They already demonstrate DNA sequencing.
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller ExamsRevision. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $3.18. You're not tied to anything after your purchase.
