NURS 3305 & 5005 Infectious Disease Drug Tables.
Narrow vs Broad spectrum: Narrow is preferred to reduce resistance to antibiotics. - refers to the spectrum of what it can treat. Empiric Therapy: using what works.
Bacteriostatic: suppress growth of bacteria, if pt if immunocompromised (wbc) �...
Narrow vs Broad spectrum: Narrow is preferred to reduce resistance to antibiotics. - refers to the spectrum of what it can treat.
Empiric Therapy: using what works.
Bacteriostatic: suppress growth of bacteria, if pt if immunocompromised (wbc) – not as effective
Bactericidal: kill bacteria ..work with patients works with patents to be immunocompromised
Prototype Class Uses MOA SE Notes
CELL WALL INHIBITORSBACTERIAL
PENICILLINS (and related drug)- Inhibiting cell wall
GI heart burn, diarrhea, Penicillin G will not be
stomatitis, discolored affective towards a
tongue, bacteria creating
penicillinase
Multiple DDI’s
MOA: Weaken Cell wall,
Increased bleeding time of Streptococcus sp. (Active
causing bacteria to take
anticoagulants; inactivates against most Gram
up excessive water and
narrow-spectrum aminoglycosides in in same positive tentanus,
Streptococcus; many rupture. Bactericidal, only
penicillin G penicillinase sensitive IV bag; potentially decreased gangrene and anthrax,
G+ & some G- ; Syphilis killing dividing bacteria.
penicillin efficient of oral syphilis
Bind to penicillin binding
contraceptive. Mechanism of Bacterial
proteins to weaken cell
Resistance
wall.
• Inability of penicillins
to reach their target
• Inactivation of
penicillins by bacterial
enzymes (penicillinase
MOA: Weaken Cell wall,
(nafcillin) narrow-spectrum causing bacteria to take
penicillinase resistant MSSA; staphylococcus up excessive water and
(Nallpen) penicillin rupture. Bactericidal, only
killing dividing bacteria
MOA: Weaken Cell wall, Inactivated by beta-
amoxicillin AOM, PUD; H.
causing bacteria to take lactamases not so helpful
[Amoxil] broad-spectrum influenzae, E. for staphylococcus.
up excessive water and
ampicillin penicillin coli,H. pylori,
rupture. Bactericidal, only
[Marcillin] Gonorrhea, AOM
killing dividing bacteria
, NURS 3305 & 5005 Infectious Disease Drug
Tables
Same as broad-
MOA: Weaken Cell wall, Penicillinase sensitive.
causing bacteria to take
extended-spectrum spectrum, plus UTIs;
(ticarcillin) up excessive water and
penicillin Pseudomonas
rupture. Bactericidal, only
aeruginosa
killing dividing bacteria
clavulanic acid penicillinase inhibitor Combined with MOA: Weaken Cell wall, [augmentin]
amoxicillin to treat causing bacteria to take Not a penicillin, but a
up drug used in conjunction
excessive water and
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