NR 546 Antipsychotics Table Week 3 Assignments. Drug name Indication Target symptoms: state if positive or negative effect Potency (if noted. receptor occupancy if noted) Neurotransmitter(s) affected Half-life (T1/2), metabolism (CYP 450 enzyme) Notable side effects (associate to pathway or...
NR 546 Antipsychotics Table Week 3
Assignments latest 2023
, Drug name Indication Half-life (T1/2), Notable side effects (associate to pathway or NT)
Target symptoms: state if positive or negative effect metabolism
Potency (if noted. receptor occupancy if noted ) (CYP 450
Neurotransmitter(s) affected enzyme)
Typical antipsychotics (conventional)
Haloperidol Blocks dopamine 2 receptors, reducing positive Decanoate Acute blockade of dopamine 2 receptors in the
symptoms of psychosis and possibly combative, half-life striatum can cause drug-induced parkinsonism,
explosive, and hyperactive behaviors Blocks dopamine approximately dystonia, or akathisia
2 receptors in the nigrostriatal pathway, improving tics 3 weeks Oral Chronic blockade of dopamine 2 receptors in the
and other symptoms in Tourette’s syndrome. half-life striatum can cause tardive dyskinesia
approximately By blocking dopamine 2 receptors in the pituitary,
12–38 hours it can cause elevations in prolactin
By blocking dopamine 2 receptors excessively in
the mesocortical and mesolimbic dopamine
pathways, especially at high doses, it can cause
worsening of negative and cognitive symptoms
(neuroleptic-induced deficit syndrome).
Blocking alpha 1 adrenergic receptors can cause
dizziness, hypotension, and syncope
Thioridazine Blocks dopamine 2 receptors, reducing positive Metabolized Acute blockade of dopamine 2 receptors in the
symptoms of psychosis by CYP450 2D6 striatum can cause drug-induced parkinsonism,
dystonia, or akathisia.
Chronic blockade of dopamine 2 receptors in the
striatum can cause tardive dyskinesia
By blocking dopamine 2 receptors in the pituitary,
it can cause elevations in prolactin
By blocking dopamine 2 receptors excessively in
the mesocortical and mesolimbic dopamine
pathways, especially at high doses, it can cause
worsening of negative and cognitive symptoms
(neuroleptic-induced deficit syndrome)
Blocking muscarinic cholinergic receptors can
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