UNE Chem 1005 Final Questions With Complete Solutions
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CHEM 1005
Institution
University Of New England (UNE
)
In the fasted state, fatty acyl-CoAs are transported across the mitochondrial membrane. The transport of fatty acids via carnitine palmitoyl transferase 1 can be directly inhibited by which of the following compounds? correct answer: Malonyl-CoA
An individual is on a hunger strike and has not e...
une chem 1005 final questions with complete soluti
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University of New England (UNE
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CHEM 1005
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UNE Chem 1005 Final Questions With
Complete Solutions
In the fasted state, fatty acyl-CoAs are transported across the
mitochondrial membrane. The transport of fatty acids via
carnitine palmitoyl transferase 1 can be directly inhibited by
which of the following compounds? correct answer: Malonyl-
CoA
An individual is on a hunger strike and has not eaten in 13 days.
Which of the following best describes their metabolic state?
correct answer: The brain will be preferentially oxidizing
ketones.
Ketonuria, hyperglycemia and severe acidosis are prime
diagnostic indicators of the presentation of type 1 diabetes
ketoacidosis. Which of the following compounds are ketone
bodies that would be elevated in serum and urine of a patient in
this condition? correct answer: D-3-hydroxybutyrate and
acetoacetate
In liver, which of the following key inhibitory events ensures
that newly synthesized will palmitoyl-CoA is not immediately
oxidized? correct answer: Inhibition of carnitine palmitoyl
transferase 1 by malonyl-CoA
A 10-year old boy is brought to the emergency department by
his father. He reports his son has recently been very thirsty and
needing to make frequent trips to the bathroom. Physical
,examination revealed a thin boy, in the 30th percentile for height
and weight. A rapid dipstick test revealed glucose in his urine.
Evaluation of this boys blood would reveal decreased levels of
which of the following compounds or hormones? correct
answer: Insulin
A 22-year old woman engaging in a political protest goes on a
hunger strike on a prominent corner in a city park. She refuses
all offers of food except for water through the first 2 weeks.
Under these conditions there is a decreased reliance on which of
the following pathways for fuel? correct answer:
Gluconeogenesis
Which of the following is not a product of B-oxidation? correct
answer: NADPH
ATP can be generated by many metabolic pathways in the body.
Which of the following processes generated the most ATP?
correct answer: Fatty acid B-oxidation
Which of the following is the regulated step of lipogenesis in
eukaryotes? correct answer: Carboxylation of acetyl-CoA
Under fasting conditions, acetyl CoA carboxylase will be
inhibited by an increase in which of the following compounds?
correct answer: Fatty acyl-CoA
Which of the following enzymes is correctly paired with its
allosteric inhibitor? correct answer: Acetyl-CoA carboxylase :
palmitoyl-CoA
, Under conditions when glucose oxidation is elevated, the acetyl-
CoA produced will allosterically activate which of the following
enzymes leading to an increase in the production of
oxaloacetate? correct answer: Pyruvate carboxylase
Which of the following is the regulatory enzyme for fatty acid
synthesis? correct answer: Acetyl CoA carboxylase
In the case of deficiency of biotin, which of the following
enzymes required for fatty acid metabolism will be impaired?
correct answer: Acetyl-CoA carboxylase
NADPH is essential for fatty acid synthesis can be generated by
which of the following enzymes? correct answer: Glucose 6
phosphate dehydrogenase and malic enzyme
An increase in the ratio of insulin to glucagon will increase the
activity in of which of the following enzymes? correct answer:
Acetyl-CoA carboxylase, phosphofructokonase 2 and glycogen
synthase (hormone sensitive lipase will be decreased)
Shortly after meal high in fat, you would expect an elevation of
which of the follow lipoproteins in circulation? correct answer:
Chylomicrons
A 45-year-old man is found to have an elevated serum
triglycerides of > 730mg/dL. He tells you he forgot to fast
before his visit and he ate a full breakfast of bacon and eggs
before the labs were drawn. Which of the following lipoproteins
would be the largest contributors to a measurement of plasma
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