Hematology USMLE step 1 Exam Questions & Answers 2023/2024
What transporter is found on Erythrocytes and what is the function? - ANSWER-HCO3-/Cl- antiporter
HCO3- leaves the RBC and Cl- moves into RBC (chloride shift)
Source of energy for RBC and how is it used? - ANSWER-GLUCOSE
- 90% i...
Hematology USMLE step 1 Exam
Questions & Answers 2023/2024
What transporter is found on Erythrocytes and what is the function? - ANSWER-HCO3-/Cl- antiporter
HCO3- leaves the RBC and Cl- moves into RBC (chloride shift)
Source of energy for RBC and how is it used? - ANSWER-GLUCOSE
- 90% in glycolysis
- 10% in HMP shunt
Platelets
a. Life span
b. Function
c. Where are they stored? - ANSWER-a. 8-10 days
b. Primary hemostasis (forms platelet plug by aggregating and sticking to fibrinogen)
c. Spleen (1/3 of them are there)
Granules of Platelets contain - ANSWER-Dense granules: ADP, Ca+2. TXA2
alpha granules: vWF, Fibrinogen
Thrombopoietin
a. Made where?
b. Function - ANSWER-a. Liver and kidney
b. Causes megakaryocytes to proliferate/differentiate and make platelets
,vWF receptor on platelet - ANSWER-Gp Ib
Fibrinogen receptor on platelet - ANSWER-Gp IIb/IIIa
Thrombocytopenia results in ____. - ANSWER-Petechiae
Neutrophilic specific granules contain what? - ANSWER-ALP (alkaline phosphatase)
Function of Basophils - ANSWER-Mediate allergic reactions
What do Basophils secrete? - ANSWER-- Histamine (in granules)
- Heparin (in granules)
- Leukotrienes (synthesize on demand)
Causes of Basophilia - ANSWER-- CML ****
- Hypersensitivity reactions
Types of Lymphocytes - ANSWER-B cells
T cells
NK cells
What do lymphocytes produce? - ANSWER-Hematopoietic growth factors
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