PCOA - Pharmaceutical Sciences Questions and Answers Graded A+
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PCOA - Pharmaceutical Sciences Questions and Answers Graded A+
What effects does change in structure and as a result biodistribution have on a drug?
(Physico-Chemical Properties of Drugs) Changes the
solubility, metabolism, and excretion
properties of the drug within the limits of the biologica...
what effects does change in structure and as a res
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PCOA - Pharmaceutical Sciences
Questions and Answers Graded A+
What effects does change in structure and as a result biodistribution have on a drug?
(Physico-Chemical Properties of Drugs) ✔✔Changes the
solubility,
metabolism, and
excretion
properties of the drug within the limits of the biological target.
Electrolytes ✔✔Ionic/ weak acid or base
Hydrogen Bonds ✔✔Hydrogen bonds form between polar groups
Interaction between an electronegative atom (O, N, S) and a polarized hydrogen.
, Polarized H is one that is bound to an electronegative atom.
Water can accept and donate H-bonds. Competition between H-bonding between water
molecules v. H-bonding between drug and water molecules
Halogenated hydrocarbon ✔✔contain C, H, and halides (CL, F, I)
Alcohols ✔✔Contain a hydrogen bond donor and acceptor
R-OH
aldehyde ✔✔O=C-H
pKa value ✔✔Definition: a measure of the tendency to give up a proton
indicates the acid or base properties of a particular functional group
As pKa decreases, the better the acid, the easier it is to give up a proton.
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