NR-566 Advanced Pharmacology for Care of the Family NR566 Midterm Exam Week 4 Orlistat - GI effects are common. A pproximately 20 to 30% of patients experience oily rectal leakage, flatulence with discharge, fecal urgency and fatty or oily stools. Another 10% experience increased defecation and fecal incontinence. All of these are the result of reduce fat absorption, and all can be minimized by reducing fat intake. Dosing with psyllium (Metamucil and others), a bulk forming laxative can also reduce GI effects. The underlying mechanism is the absorption of dietary fat by psyllium. Orlistat pt. education - Take multivitam ins 2 hours before or after to supplement the fat -
soluble vitamins that may not be absorbed well. Orlistat symptoms to report - Itching, vomiting, jaundice, anorexia, fatigue, dark urine & light-
colored stools - all can be associated with severe liver damage . Should report s/s immediately & discharge use until liver injury has been ruled out.
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