Summary of Triglyceride Synthesis and Mobilization.
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Course
Biochemistry
Institution
China Medical University
This document provides a simple illustration of triglyceride synthesis and mobilization metabolisms in human body. It’s easy to comprehend and good for pre-test review.
Triglyceride Synthesis (Lipogenesis) Adip
ce
After making the three molecules of fatty acids with
CoA from fatty acids synthesis. They're called (Fatty s
Acyl CoA), they must be linked into a chain called
glycerol. This metabolism mainly occurs in the liver. I FA CoA's
pp
—————————————- E
pig I
How can we get the glycerol chain? con
I cth CCHYCH
1. From lipolysis of Fats to glycerol and then convert it
into Glycerol-3-Phosphate by Glycerol kinase enzyme. E
G
2. Or converting DHAP that comes from Glycolysis into
Glycerol-3-Phosphate.
2
j É CH Hz CH CH CH CoA
Now the process of combining the Glycerol-3P with three
molecules of Fatty Acyl CoA's.
I
jig cha coital c't con
——————————————- S
Firstly, the FA CoAs are added in a sequence. Beginning
with the first FA CoA combines with the first carbon at
the Glycerol chain. It's catalyzed by (the Acyl
I
Transferase enzyme). And popping off the CoA. The new
molecule is called (Lysophosphatidic Acid) (MAG)
I FA COA
I
Secondly, the 2nd FA CoA has to be unsaturated. And
then binds with the 2nd carbon on the chain catalyzed
I I Élo'tÉ it
by the same enzyme. The molecule is called (Phosphatidic I poi d In Acyltransferas
acid) (DAG) I
s
Lastly, before adding the last FA CoA, we first have to
get rid of the phosphate group on the 3rd carbon by a
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