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USMLE step 1 - equations

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Sensitivity Sensitivity = TP / (TP + FN) Specificity Specificity = TN / (TN + FP) Positive predictive value PPV = TP / (TP + FP) Negative predictive value NPV = TN / (TN + FN) Relative risk RR= (a/[a+b]) / (c/[c+d]) Attributable risk AR= (a/[a+b]) - (c/[c+d]) Num...

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  • August 9, 2022
  • 2
  • 2022/2023
  • Exam (elaborations)
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USMLE step 1 - equations
Sensitivity - answerSensitivity = TP / (TP + FN)

Specificity - answerSpecificity = TN / (TN + FP)

Positive predictive value - answerPPV = TP / (TP + FP)

Negative predictive value - answerNPV = TN / (TN + FN)

Relative risk - answerRR= (a/[a+b]) / (c/[c+d])

Attributable risk - answerAR= (a/[a+b]) - (c/[c+d])

Number needed to treat - answer1/absolute risk reduction

Number needed to harm - answer1/attributable risk

Hardy-Weinberg equilibrium - answerp^2 + 2pq + q^2 = 1
p+q=1

Henderson-Hasselbalch equation - answerpH = pKa + log [HCO3-] / 0.03PCO2

Volume of distribution - answerVd = amount of drug in the body/ plasma drug
concentration

Clearance - answerCL = rate of elimination of drug/ plasma drug concentration

Half-life - answert1/2 = (0.7xVd)/ CL

Loading dose - answerLD= (target plasma concentration × Vd × wt in kg) / bioavailability

Maintenance dose - answerMD= (target plasma concentration × CL × wt in kg) /
bioavailability

Cardiac output (O2 consumption) - answerCO = rate of 02 consumption/ (arterial 02
content - venous 02 content)

Cardiac output (HR) - answerCO = stroke volume x heart rate

Mean arterial pressure - answerMAP = cardiac output x total peripheral resistance
MAP = 1/3 systolic + 2/3 diastolic

Stroke volume - answerSV = end diastolic volume - end systolic volume

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